J
Jennifer K. Thompson
Researcher at Walter and Eliza Hall Institute of Medical Research
Publications - 55
Citations - 5383
Jennifer K. Thompson is an academic researcher from Walter and Eliza Hall Institute of Medical Research. The author has contributed to research in topics: Plasmodium falciparum & Gene. The author has an hindex of 34, co-authored 53 publications receiving 5004 citations. Previous affiliations of Jennifer K. Thompson include Royal Melbourne Hospital & University of Melbourne.
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Amplification of the multidrug resistance gene in some chloroquine-resistant isolates of P. falciparum.
TL;DR: The existence of an mdr gene in P. falciparum and its amplification in some chloroquine-resistant lines greatly adds to the circumstantial evidence that pfmdr mediateschloroquine resistance in these lines.
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Heterochromatin Silencing and Locus Repositioning Linked to Regulation of Virulence Genes in Plasmodium falciparum
Manoj T. Duraisingh,Till S. Voss,Allison J. Marty,Allison J. Marty,Michael F. Duffy,Robert T. Good,Jennifer K. Thompson,Lucio H. Freitas-Junior,Artur Scherf,Brendan S. Crabb,Alan F. Cowman +10 more
TL;DR: It is demonstrated that both a subtelomeric transgene and var genes are subject to reversible gene silencing, which implies that locus repositioning and heterochromatic silencing play important roles in the epigenetic regulation of virulence genes in P. falciparum.
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Selection for mefloquine resistance in Plasmodium falciparum is linked to amplification of the pfmdr1 gene and cross-resistance to halofantrine and quinine.
TL;DR: In this paper, two chloroquine-resistant cloned isolates of Plasmodium falciparum were subjected to mefloquine selection to test if this resulted in alterations in chloroquines sensitivity and amplification of the pfmdr1 gene.
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A var gene promoter controls allelic exclusion of virulence genes in Plasmodium falciparum malaria
Till S. Voss,Julie Healer,Allison J. Marty,Allison J. Marty,Michael F. Duffy,Jennifer K. Thompson,James G. Beeson,John C. Reeder,Brendan S. Crabb,Alan F. Cowman +9 more
TL;DR: It is shown that a var promoter is sufficient for epigenetic silencing and mono-allelic transcription of this virulence gene family, and are fundamental for the understanding of antigenic variation in P. falciparum-mediated virulence and immune evasion.
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The adhesion of Plasmodium falciparum-infected erythrocytes to chondroitin sulfate A is mediated by P. falciparum erythrocyte membrane protein 1
John C. Reeder,Alan F. Cowman,Kathleen M. Davern,James G. Beeson,James G. Beeson,Jennifer K. Thompson,Stephen J. Rogerson,Stephen J. Rogerson,Graham Brown +8 more
TL;DR: Evidence is presented that the P. falciparum erythrocyte membrane protein 1 product of the gene is the parasite ligand mediating CSA binding, paving the way to a more detailed understanding of the pathogenesis of placental infection and potential therapeutic strategies targeting the interaction.