Kyung Chin

TL;DR: The present study demonstrates the existence of mRNA for erythropoietin receptor in human umbilical vein endothelial cells and reverse transcribed mRNA of endothelium and used different PCR primers to amplify erythroleukemia cell line target cDNA between exons 5 and 6.

TL;DR: Describing the human EpoR transcript in brain and neuronal cells to determine its contribution in regulating the Epo response in brain suggests that in contrast to erythropoiesis, the neuroprotective effect of Epo and its receptor may require two molecular events: the induction ofEpo production by hypoxia and an increase inEpoR expression in neuronal cells resulting in increased sensitivity to Epo.

TL;DR: Data indicate that thalidomide induces increased expression of the gamma-globin gene via ROS-dependent activation of the p38 MAPK signaling pathway and histone H4 acetylation.

TL;DR: The data suggest that the hEpoR transgene contains appropriate regulatory sequences to direct tissue specific expression in tissues associated with hematopoietic activity and in the embryonic brain, but lacks the control elements to provide levels of expression comparable to that of the endogenous gene or to selectively silence brain expression in the adult mouse.

TL;DR: A genomic clone of the human erythropoietin (Epo) receptor is isolated and characterized from a placental genomic library using a cDNA probe for the murine Epo receptor to help elucidate aspects of the transcriptional and possible translational control of the Epo receptors in human ERYthroid cells and thus its role in signal transduction and erythroid differentiation.