C
Constance Tom Noguchi
Researcher at National Institutes of Health
Publications - 163
Citations - 8840
Constance Tom Noguchi is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Erythropoietin & Erythropoietin receptor. The author has an hindex of 51, co-authored 159 publications receiving 8295 citations. Previous affiliations of Constance Tom Noguchi include University of Illinois at Chicago & Nippon Medical School.
Papers
More filters
Journal ArticleDOI
Erythropoietin receptor mRNA expression in human endothelial cells.
Athanasius Anagnostou,Ziyao Liu,Manfred Steiner,Kyung Chin,Eun Sun Lee,Noubar Kessimian,Constance Tom Noguchi +6 more
TL;DR: The present study demonstrates the existence of mRNA for erythropoietin receptor in human umbilical vein endothelial cells and reverse transcribed mRNA of endothelium and used different PCR primers to amplify erythroleukemia cell line target cDNA between exons 5 and 6.
Journal ArticleDOI
Erythropoietin receptor signalling is required for normal brain development
Xiaobing Yu,John J. Shacka,Jeffrey B. Eells,Carlos A. Suárez-Quian,Ronald M. Przygodzki,Bojana B. Beleslin-Cokic,Chyuan-Sheng Lin,Vera M. Nikodem,Barbara L. Hempstead,Kathleen C. Flanders,Frank Costantini,Constance Tom Noguchi +11 more
TL;DR: Evidence is provided that erythropoietin acts to stimulate neural progenitor cells and to prevent apoptosis in the embryonic brain and that induction of erythroid differentiation and its receptor by hypoxia may contribute to selective cell survival in the brain.
Journal ArticleDOI
Erythropoietin and hypoxia stimulate erythropoietin receptor and nitric oxide production by endothelial cells
Bojana B. Beleslin-Cokic,Vladan P. Čokić,Xiaobing Yu,Babette B. Weksler,Alan N. Schechter,Constance Tom Noguchi +5 more
TL;DR: It is suggested that low oxygen tension increases endothelial cell capacity to produce NO in response to EPO by induction of both EPOR and eNOS, which may be a physiologically relevant mechanism to counterbalance the hypertensive effects of increased hemoglobin-related NO destruction resulting from hypoxia-induced increased red cell mass.
Journal ArticleDOI
Hematologic responses of patients with sickle cell disease to treatment with hydroxyurea.
Griffin P. Rodgers,George J. Dover,Constance Tom Noguchi,Alan N. Schechter,Arthur W. Nienhuis +4 more
TL;DR: It is concluded that hydroxyurea is effective in increasing the production of fetal hemoglobin, which in this study was found to be associated with a small decrease in hemolysis and an increase in hemoglobin levels despite myelosuppression.
Journal ArticleDOI
Erythropoietin Stimulates Proliferation and Interferes with Differentiation of Myoblasts
Martha Ogilvie,Xiaobing Yu,Valerie Nicolas-Metral,Silvia M. Pulido,Chun Liu,Urs T. Ruegg,Constance Tom Noguchi +6 more
TL;DR: Data suggest that, rather than acting in an instructive or specific mode for differentiation, Epo can stimulate proliferation of myoblasts to expand the progenitor population during differentiation and may have a potential role in muscle development or repair.