K
Kyung Ko
Researcher at New York University
Publications - 12
Citations - 2902
Kyung Ko is an academic researcher from New York University. The author has contributed to research in topics: Phosphatase & T cell. The author has an hindex of 12, co-authored 12 publications receiving 2796 citations. Previous affiliations of Kyung Ko include Hospital Research Foundation.
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Journal ArticleDOI
In Vivo Depletion of CD11c+ Dendritic Cells Abrogates Priming of CD8+ T Cells by Exogenous Cell-Associated Antigens
Steffen Jung,Derya Unutmaz,Phillip Wong,Gen Ichiro Sano,Kenia De Los Santos,Tim Sparwasser,Shengji Wu,Sri Vuthoori,Kyung Ko,Fidel Zavala,Eric G. Pamer,Dan R. Littman,Richard A. Lang +12 more
TL;DR: A novel diphtheria toxin-based system that allows the inducible, short-term ablation of dendritic cells (DC) in vivo is reported and it is shown that in vivo DC are required to cross-prime CTL precursors.
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Conditional Macrophage Ablation Demonstrates That Resident Macrophages Initiate Acute Peritoneal Inflammation
Jean Francois Cailhier,Marina Partolina,Srilatha Vuthoori,Shengji Wu,Kyung Ko,Simon Watson,John Savill,Jeremy Hughes,Richard A. Lang +8 more
TL;DR: A key role is indicated for resident peritoneal Mφ in sensing perturbation to the peritoneum microenvironment and regulating PMN infiltration in experimental peritonitis.
Journal ArticleDOI
Histidine phosphorylation of the potassium channel KCa3.1 by nucleoside diphosphate kinase B is required for activation of KCa3.1 and CD4 T cells
Shekhar Srivastava,Zhai Li,Kyung Ko,Papiya Choudhury,Mamdouh Albaqumi,Amanda K. Johnson,Ying Yan,Jonathan M. Backer,Derya Unutmaz,William A. Coetzee,Edward Y. Skolnik +10 more
TL;DR: It is shown that nucleoside diphosphate kinase B (NDPK-B), a mammalian histidine kinase, functions downstream of PI(3)P to activate KCa3.1, and this findings provide one of the best examples whereby histidine phosphorylation regulates a biological process in mammals.
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Fgf receptor signaling plays a role in lens induction.
Sonya C. Faber,Patricia Dimanlig,Helen P. Makarenkova,Sanjay Shirke,Kyung Ko,Richard A. Lang,Richard A. Lang +6 more
TL;DR: Experiments show that fibroblast growth factor receptor (Fgfr) signaling plays a role in lens induction and define a genetic pathway in which Fgfr and Bmp7 signaling converge on Pax6 expression in the lens placode with the Foxe3 and Sox2 genes lying downstream.
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VEGF deprivation-induced apoptosis is a component of programmed capillary regression.
TL;DR: Inhibition of VEGF in vivo using fusion proteins of the human Flk-1/KDR receptor resulted in a significantly increased number of capillaries showing synchronous apoptosis, providing evidence that V EGF is necessary for endothelial cell survival in this system and in addition, that VegF deprivation mediated by flow cessation is a component of synchronous suicides.