F
Fidel Zavala
Researcher at Johns Hopkins University
Publications - 184
Citations - 13537
Fidel Zavala is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Circumsporozoite protein & Epitope. The author has an hindex of 61, co-authored 173 publications receiving 12495 citations. Previous affiliations of Fidel Zavala include New York University & Walter Reed Army Institute of Research.
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Journal ArticleDOI
In Vivo Depletion of CD11c+ Dendritic Cells Abrogates Priming of CD8+ T Cells by Exogenous Cell-Associated Antigens
Steffen Jung,Derya Unutmaz,Phillip Wong,Gen Ichiro Sano,Kenia De Los Santos,Tim Sparwasser,Shengji Wu,Sri Vuthoori,Kyung Ko,Fidel Zavala,Eric G. Pamer,Dan R. Littman,Richard A. Lang +12 more
TL;DR: A novel diphtheria toxin-based system that allows the inducible, short-term ablation of dendritic cells (DC) in vivo is reported and it is shown that in vivo DC are required to cross-prime CTL precursors.
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Cloned cytotoxic T cells recognize an epitope in the circumsporozoite protein and protect against malaria
Pedro Romero,Janet L. Maryanski,Giampietro Corradin,Ruth S. Nussenzweig,Victor Nussenzweig,Fidel Zavala +5 more
TL;DR: In this article, an epitope contained within amino acids 249-260 of the Plasmodium berghei circumsporozoite protein was identified by H-2Kd-restricted cytotoxic T cells.
Journal Article
Comparative testing of monoclonal antibodies against Plasmodium falciparum sporozoites for ELISA development.
Robert A. Wirtz,Fidel Zavala,Y. Charoenvit,Gary H. Campbell,Thomas R. Burkot,Imogene Schneider,K. M. Esser,R. L. Beaudoin,R. G. Andre +8 more
TL;DR: Two monoclonal antibodies developed against Plasmodium falciparum sporozoites at four institutions were evaluated for use in an enzyme-linked immunosorbent assay (ELISA) and one had the highest sensitivity, a requirement for lower concentrations of capture antibody, and had been tested successfully against sporozoite from a wider range of geographical areas than the others.
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Quantification of antigen specific CD8+ T cells using an ELISPOT assay
Yasushi Miyahira,Kenichiro Murata,Dolores Rodríguez,Juan Ramón Rodríguez,Mariano Esteban,Mauricio M. Rodrigues,Fidel Zavala +6 more
TL;DR: This ELISPOT assay can be performed with spleen cells from immunized mice, and provide the precise number of antigen specific CD8+ T cells present in mixed lymphocyte populations, and is more sensitive than the chromium-51 release assay, and much simpler than the conventional precursor frequency analysis.
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Rationale for Development of a Synthetic Vaccine Against Plasmodium falciparum Malaria
Fidel Zavala,James P. Tam,M. R. Hollingdale,Allan H. Cochrane,Isabella A. Quakyi,Ruth S. Nussenzweig,V Nussenzweig +6 more
TL;DR: It is shown that the dominant epitope of Plasmodium falciparum is contained in the synthetic dodecapeptide Asn-Ala-Asn-Pro-As n-NANP-Pro, which is a logical target for vaccine development.