Showing papers by "L. Ashley Cowart published in 2007"

TL;DR: Due to many factors including ease of culture and genetic modification, and conservation of major sphingolipid metabolic pathways, Saccharomyces cerevisiae has served as an ideal model system with which to identify enzymes of sphingoipid biosynthesis and to dissect sphingoripid function.

TL;DR: It is suggested that Isc1p generates ceramide in mitochondria, and the generated ceramide contributes to the normal function of mitochondria.

TL;DR: Data presented indicate that heat does not directly alter the in vitro activity of serine palmitoyltransferase (SPT), the enzyme responsible for initiating de novo sphingolipid synthesis, and indicates that SPT activity can be driven by several factors that increase serine uptake in the absence of heat.

TL;DR: EETs-induced up-regulation of eNOS phosphorylation and expression appears to involve in both PI3K/Akt and MAPK pathways and administration of viral CYP epoxygenases expression vectors into rats enhanced eN OS phosphorylated and function in vivo.