L. Henry Goodnough

TL;DR: The transcriptional landscape of the four human HOX loci is characterized at five base pair resolution in 11 anatomic sites and 231 HOX ncRNAs are identified that extend known transcribed regions by more than 30 kilobases, suggesting transcription of ncRNA may demarcate chromosomal domains of gene silencing at a distance.

TL;DR: The hypothesis that Wnt signaling is an evolutionarily conserved mechanism controlling facial morphogenesis is tested by determining the pattern of Wnt responsiveness in avian faces, and the consequences of WNT inhibition in the chick face are evaluated.

TL;DR: It is shown in mice that removal of β-catenin from skull bone progenitors results in the near complete transformation of the skull bones to cartilage, whereas constitutive β- catenin activation inhibits skull bone fate selection.

TL;DR: Ectoderm Wnt ligands induce osteoblast and dermal fibroblast progenitor specification while initiating expression of a subset of mesenchymal Wnts, and ectoderm-derived Wntligands provide an inductive cue to the cranial mesenchyme for the fate selection of dermal Fibroblast and osteOBlast lineages.

TL;DR: It is shown that overexpression of spry2 at the initiation of craniofacial development results in a dramatic arrest in outgrowth of the facial prominences, and this data suggest that Sprouty2 plays a role in the out growth of facial Prominences independent of canonical Fgf signaling.