L. O. Bryzgalov

TL;DR: In this paper, the authors investigated the methylation status in blood samples of 32 healthy donors and 60 lung cancer patients before and after treatment with neoadjuvant chemotherapy followed by total tumor resection.

TL;DR: DiChIPMunk as discussed by the authors constructs TFBS models as optimal dinucleotide PWMs, thus accounting for correlations between nucleotides neighboring in input sequences, and demonstrate that diPWMs constructed by diChIPmunk outperform traditional PWMs trained on ChIP-Seq data.

TL;DR: Nuclear and mitochondrial cirDNA levels in plasma and on the surface of blood cells are modulated in RA and combination of cirDNA values with ACPA can improve the serological diagnosis of RA.

TL;DR: An approach aggregating the whole set of ENCODE ChIP-seq data in order to search for rSNPs is described, and experimental evidence of its efficiency is provided, based on the assumption that the enrichment of a genomic region with transcription factor binding loci indicates its regulatory function and thereby SNPs located in this region are more likely to influence transcription regulation.

TL;DR: The data show that the development of depression under social stress conditions is correlated with suppression of the overactive molecular response to induced stress, involving gene regulatory resistance to glucocorticoid molecules, potentially via a chromatin remodeling mechanism.