Near infrared spectroscopy: A mature analytical technique with new perspectives - A review.

Current trends and future perspectives of solid dispersions containing poorly water-soluble drugs.

https://biblio.ugent.be/publication/2919697/file/2919786.pdf

Near infrared and Raman spectroscopy for the in-process monitoring of pharmaceutical production processes.

Hot-melt extrusion (HME) is a promising technology for the production of new chemical entities in the developmental pipeline and for improving products already on the market. In drug discovery and development, industry estimates that more than 50% of active pharmaceutical ingredients currently used belong to the biopharmaceutical classification system II (BCS class II), which are characterized as poorly water-soluble compounds and result in formulations with low bioavailability. Therefore, there is a critical need for the pharmaceutical industry to develop formulations that will enhance the solubility and ultimately the bioavailability of these compounds. HME technology also offers an opportunity to earn intellectual property, which is evident from an increasing number of patents and publications that have included it as a novel pharmaceutical formulation technology over the past decades. This review had a threefold objective. First, it sought to provide an overview of HME principles and present detailed engineered extrusion equipment designs. Second, it included a number of published reports on the application of HME techniques that covered the fields of solid dispersions, microencapsulation, taste masking, targeted drug delivery systems, sustained release, films, nanotechnology, floating drug delivery systems, implants, and continuous manufacturing using the wet granulation process. Lastly, this review discussed the importance of using the quality by design approach in drug development, evaluated the process analytical technology used in pharmaceutical HME monitoring and control, discussed techniques used in HME, and emphasized the potential for monitoring and controlling hot-melt technology.

/pdf/hot-melt-extrusion-from-theory-to-application-in-3lrysbwbms.pdf

Hot-Melt Extrusion: from Theory to Application in Pharmaceutical Formulation

Assessment of Recent Process Analytical Technology (PAT) Trends: A Multiauthor Review

https://biblio.ugent.be/publication/1262698/file/1262783.pdf

Raman spectroscopy for the in-line polymer-drug quantification and solid state characterization during a pharmaceutical hot-melt extrusion process.

https://biblio.ugent.be/publication/3062438/file/3062458.pdf

In-line NIR spectroscopy for the understanding of polymer–drug interaction during pharmaceutical hot-melt extrusion

https://biblio.ugent.be/publication/3062003/file/3062071.pdf

Co-extrusion as manufacturing technique for fixed-dose combination mini-matrices.

https://biblio.ugent.be/publication/3163321/file/3163380.pdf

L. Saerens

Papers

Near infrared and Raman spectroscopy for the in-process monitoring of pharmaceutical production processes.

Raman spectroscopy for the in-line polymer-drug quantification and solid state characterization during a pharmaceutical hot-melt extrusion process.

In-line NIR spectroscopy for the understanding of polymer–drug interaction during pharmaceutical hot-melt extrusion

Co-extrusion as manufacturing technique for fixed-dose combination mini-matrices.

Detection of counterfeit Viagra by Raman microspectroscopy imaging and multivariate analysis