L
Laila C. Roisman
Researcher at Ben-Gurion University of the Negev
Publications - 50
Citations - 2117
Laila C. Roisman is an academic researcher from Ben-Gurion University of the Negev. The author has contributed to research in topics: Lung cancer & Medicine. The author has an hindex of 17, co-authored 40 publications receiving 1667 citations. Previous affiliations of Laila C. Roisman include Monash University, Clayton campus & Rabin Medical Center.
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Journal ArticleDOI
Tau-mediated iron export prevents ferroptotic damage after ischemic stroke
Qing-Zhang Tuo,Qing-Zhang Tuo,Qing-Zhang Tuo,Peng Lei,Peng Lei,Katherine A Jackman,Li Xl,Huan Xiong,Zhen-Yu Liuyang,Laila C. Roisman,Zhang St,Scott Ayton,Qiang Wang,Peter J. Crouch,Katherine Ganio,Xiu-Lian Wang,Lei Pei,Paul A. Adlard,Youming Lu,Roberto Cappai,Jian-Zhi Wang,Rong Liu,Ashley I. Bush +22 more
TL;DR: Tau–iron interaction is introduced as a pleiotropic modulator of ferroptosis and ischemic stroke outcome and the protective benefit of tau knockout was revived in older mice by iron-targeting interventions.
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Inquiring into the Differential Action of Interferons (IFNs): an IFN-α2 Mutant with Enhanced Affinity to IFNAR1 Is Functionally Similar to IFN-β
Diego Jaitin,Laila C. Roisman,Eva Jaks,Martynas Gavutis,Jacob Piehler,Jose Van der Heyden,Gilles Uzé,Gideon Schreiber +7 more
TL;DR: It is shown that the differential activities of IFN-β are directly related to the binding affinity for IFNAR1, and conservation of the residues mutated in the HEQ mutant within IFn-α subtypes suggests that IFN,α has evolved to bind IFN AR1 weakly, apparently to sustain differential levels of biological activities compared to those induced by IFN -β.
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DNA repair of oxidative DNA damage in human carcinogenesis: Potential application for cancer risk assessment and prevention
TL;DR: A new approach based on the functional analysis of DNA repair enzymatic activity showed that reduced activity of 8-oxoguanine DNA glycosylase (OGG) is a risk factor in lung and head and neck cancer.
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Interferon-ε protects the female reproductive tract from viral and bacterial infection.
Ka Yee Fung,Niamh E. Mangan,Helen E. Cumming,Jay C. Horvat,Jemma R. Mayall,Sebastian Stifter,Nicole Anne De Weerd,Laila C. Roisman,Laila C. Roisman,Jamie Rossjohn,Sarah A. Robertson,John E. Schjenken,Belinda S. Parker,Belinda S. Parker,Caroline E. Gargett,Caroline E. Gargett,Hong P. T. Nguyen,Daniel J.J. Carr,Philip M. Hansbro,Paul J. Hertzog +19 more
TL;DR: IFN-ε–deficient mice had increased susceptibility to infection of the FRT by the common sexually transmitted infections (STIs) herpes simplex virus 2 and Chlamydia muridarum, and may be important in combating STIs that represent a major global health and socioeconomic burden.
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New Structural and Functional Aspects of the Type I Interferon-Receptor Interaction Revealed by Comprehensive Mutational Analysis of the Binding Interface
TL;DR: In this paper, the authors quantitatively mapped the complete binding region of ifnar2 on interferon (IFN)α2 by 35 individual mutations to alanine and isosteric residues.