L
Lei Pei
Researcher at Huazhong University of Science and Technology
Publications - 51
Citations - 2297
Lei Pei is an academic researcher from Huazhong University of Science and Technology. The author has contributed to research in topics: Stroke & Inflammation. The author has an hindex of 23, co-authored 46 publications receiving 1619 citations. Previous affiliations of Lei Pei include Tongji Medical College & Netherlands Institute for Neuroscience.
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Journal ArticleDOI
Tau-mediated iron export prevents ferroptotic damage after ischemic stroke
Qing-Zhang Tuo,Qing-Zhang Tuo,Qing-Zhang Tuo,Peng Lei,Peng Lei,Katherine A Jackman,Li Xl,Huan Xiong,Zhen-Yu Liuyang,Laila C. Roisman,Zhang St,Scott Ayton,Qiang Wang,Peter J. Crouch,Katherine Ganio,Xiu-Lian Wang,Lei Pei,Paul A. Adlard,Youming Lu,Roberto Cappai,Jian-Zhi Wang,Rong Liu,Ashley I. Bush +22 more
TL;DR: Tau–iron interaction is introduced as a pleiotropic modulator of ferroptosis and ischemic stroke outcome and the protective benefit of tau knockout was revived in older mice by iron-targeting interventions.
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NLRP3 Inflammasome in Neurological Diseases, from Functions to Therapies.
TL;DR: A series of promising therapeutic approaches that target theNLRP3 inflammasome signaling including anti-IL-1 therapy, small molecule NLRP3 inhibitors and other compounds are reviewed, however, these approaches are still experimental in neurological diseases.
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EPAC null mutation impairs learning and social interactions via aberrant regulation of miR-124 and Zif268 translation
Ying Yang,Xiaogang Shu,Xiaogang Shu,Dan Liu,You Shang,You Shang,Yan Wu,Yan Wu,Lei Pei,Xin Xu,Qing Tian,Jian Zhang,Kun Qian,Ya-Xian Wang,Ronald S. Petralia,Weihong Tu,Ling-Qiang Zhu,Jian-Zhi Wang,Youming Lu,Youming Lu +19 more
TL;DR: It is shown that EPAC null mutation impairs long-term potentiation (LTP) and that this impairment is paralleled with the severe deficits in spatial learning and social interactions and is mediated in a direct manner by miR-124 transcription and Zif268 translation.
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A novel mechanism of memory loss in Alzheimer’s disease mice via the degeneration of entorhinal–CA1 synapses
Xin Yang,Chengye Yao,Tian Tian,Xiong Li,Huanhuan Yan,Jun Wu,Hao Li,Lei Pei,Deming Liu,Qing Tian,Ling-Qiang Zhu,Youming Lu +11 more
TL;DR: It is reported that the synaptic terminals of pyramidal neurons in the EC layer II (ECIIPN) directly innervate CA1 parvalbumin neurons (CA1PV) and are selectively degenerated in AD mice, which exhibit amyloid-β plaques similar to those observed in AD patients.
Journal ArticleDOI
Hypothalamic neuropeptide Y (NPY) controls hepatic VLDL-triglyceride secretion in rats via the sympathetic nervous system.
Eveline Bruinstroop,Lei Pei,Mariëtte T. Ackermans,Ewout Foppen,Anke J. Borgers,Joan Kwakkel,Anneke Alkemade,Eric Fliers,Andries Kalsbeek +8 more
TL;DR: It is reported that, in fasted rats, an intact hypothalamic arcuate nucleus and hepatic sympathetic innervation are necessary to maintain VLDL-TG secretion.