L
Lakshmi Puttagunta
Researcher at University of Alberta
Publications - 58
Citations - 3944
Lakshmi Puttagunta is an academic researcher from University of Alberta. The author has contributed to research in topics: Syk & Inflammation. The author has an hindex of 24, co-authored 56 publications receiving 3689 citations. Previous affiliations of Lakshmi Puttagunta include University of Alberta Hospital.
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Journal ArticleDOI
A Mitochondria-K+ Channel Axis Is Suppressed in Cancer and Its Normalization Promotes Apoptosis and Inhibits Cancer Growth
Sébastien Bonnet,Stephen L. Archer,Joan Allalunis-Turner,Alois Haromy,Christian Beaulieu,Richard B. Thompson,Christopher T. Lee,Gary D. Lopaschuk,Lakshmi Puttagunta,Sandra Bonnet,Gwyneth Harry,Kyoko Hashimoto,Christopher J. Porter,Miguel A. Andrade,Bernard Thébaud,Evangelos D. Michelakis +15 more
TL;DR: The unique metabolic profile of cancer (aerobic glycolysis) might confer apoptosis resistance and be therapeutically targeted and the orally available DCA is a promising selective anticancer agent.
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Gene therapy targeting survivin selectively induces pulmonary vascular apoptosis and reverses pulmonary arterial hypertension
M. Sean McMurtry,Stephen L. Archer,Dario C. Altieri,Sébastien Bonnet,Alois Haromy,Gwyneth Harry,Sandra Bonnet,Lakshmi Puttagunta,Evangelos D. Michelakis +8 more
TL;DR: Inhibition of the inappropriate expression of survivin that accompanies human and experimental PAH is a novel therapeutic strategy that acts by inducing vascular mitochondria-dependent apoptosis.
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Dichloroacetate, a Metabolic Modulator, Prevents and Reverses Chronic Hypoxic Pulmonary Hypertension in Rats Role of Increased Expression and Activity of Voltage-Gated Potassium Channels
Evangelos D. Michelakis,M. Sean McMurtry,Xi Chen Wu,Jason R.B. Dyck,Rohit Moudgil,Teresa A. Hopkins,Gary D. Lopaschuk,Lakshmi Puttagunta,Ross Waite,Stephen L. Archer +9 more
TL;DR: DCA both prevents and reverses CH-PHT by a mechanism involving restoration of expression and function of Kv channels, suggesting that the beneficial effects of DCA occur by nonmetabolic mechanisms.
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Cutting Edge: Human Eosinophils Regulate T Cell Subset Selection through Indoleamine 2,3-Dioxygenase
S.O. Odemuyiwa,Ahmad Ghahary,Yunyuan Li,Lakshmi Puttagunta,Joo Eun Lee,Sorin Musat-Marcu,Aziz Ghahary,Redwan Moqbel +7 more
TL;DR: It is shown that human eosinophils constitutively express Indoleamine 2,3-dioxygenase (IDO)-catalyzed conversion of tryptophan to kynurenines (KYN), which regulates T cell function and may maintain Th2 bias through IDO.
Journal ArticleDOI
Distribution of nitric oxide synthase in normal and cirrhotic human liver
Lance McNaughton,Lakshmi Puttagunta,Maria Angeles Martinez-Cuesta,Norm Kneteman,Irvin Mayers,Redwan Moqbel,Qutayba Hamid,Marek W. Radomski +7 more
TL;DR: In this paper, the expression and activity of Nitric Oxide Syntase (NOS) proteins in healthy and diseased human livers were studied. But the authors focused on the distribution of NOS proteins in the human liver.