L
Lakshmi Santhanam
Researcher at Johns Hopkins University
Publications - 93
Citations - 3838
Lakshmi Santhanam is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Endothelial dysfunction & Arginase. The author has an hindex of 30, co-authored 80 publications receiving 3271 citations. Previous affiliations of Lakshmi Santhanam include Rensselaer Polytechnic Institute & National Institutes of Health.
Papers
More filters
Journal ArticleDOI
Arterial Stiffening Precedes Systolic Hypertension in Diet-Induced Obesity
Robert M. Weisbrod,Tina Shiang,Leona Al Sayah,Jessica L. Fry,Saumendra Bajpai,Cynthia A. Reinhart-King,Heinrich E. Lob,Lakshmi Santhanam,Gary F. Mitchell,Richard A. Cohen,Francesca Seta +10 more
TL;DR: In a diet-induced model of obesity, arterial stiffness, measured in vivo, develops within 1 month of the initiation of the diet and precedes the development of hypertension by 5 months, supporting the hypothesis that arterial stiffening is a cause rather than a consequence of hypertension.
Journal ArticleDOI
Endothelial arginase II: a novel target for the treatment of atherosclerosis.
Sungwoo Ryoo,Gaurav Gupta,Alexandre M. Benjo,Hyun Kyo Lim,Hyun Kyo Lim,Andre Camara,Gautam Sikka,Hyun Kyung Lim,Jayson S. Sohi,Lakshmi Santhanam,Kevin G. Soucy,Eric C. Tuday,Ezra Baraban,Monica Ilies,Gary Gerstenblith,Daniel Nyhan,Artin A. Shoukas,David W. Christianson,Nicholas J. Alp,Hunter C. Champion,David Huso,Dan E. Berkowitz +21 more
TL;DR: It is demonstrated that vascular endothelial arginase activity is increased in atherogenic-prone apolipoprotein E–null and wild-type mice fed a high cholesterol diet and selective arginases II inhibition or deletion prevents high-cholesterol diet–dependent decreases in vascular NO production.
Journal ArticleDOI
Arginase inhibition restores NOS coupling and reverses endothelial dysfunction and vascular stiffness in old rats.
Jae Hyung Kim,Lukasz J. Bugaj,Young Jun Oh,Young Jun Oh,Trinity J. Bivalacqua,Sungwoo Ryoo,Kevin G. Soucy,Lakshmi Santhanam,Alanah Webb,Andre Camara,Gautam Sikka,Daniel Nyhan,Artin A. Shoukas,Monica Ilies,David W. Christianson,Hunter C. Champion,Dan E. Berkowitz +16 more
TL;DR: It is demonstrated that arginase upregulation leads to endothelial nitric oxide synthase (eNOS) uncoupling and that in vivo chronic inhibition of arginases restores nitroso-redox balance, improves endothelial function, and increases vascular compliance in old rats, and suggested that arginsase is a viable target for therapy in age-dependent vascular stiffness.
Journal ArticleDOI
Inhibition of NADPH oxidase activation in endothelial cells by ortho-methoxy-substituted catechols.
David K. Johnson,Kurt J. Schillinger,David M. Kwait,Chambers V. Hughes,Erin J. McNamara,Fauod Ishmael,Robert O'Donnell,Ming-Mei Chang,Michael G. Hogg,Jonathan S. Dordick,Lakshmi Santhanam,Linda M. Ziegler,James A. Holland +12 more
TL;DR: Inhibition of endothelial NADPH oxidase by apocynin caused a dose-dependent inhibition of cell proliferation, which identifies a metabolite of an ortho-methoxy-substituted catechol, which may be the active compound formed within stimulated ECs that prevents NADPH oxidation complex assembly and activation.
Journal ArticleDOI
Inducible NO Synthase–Dependent S-Nitrosylation and Activation of Arginase1 Contribute to Age-Related Endothelial Dysfunction
Lakshmi Santhanam,Hyun Kyo Lim,Hyun Kyo Lim,Hyun Kyoung Lim,Victor Miriel,Tashalee R. Brown,Meet Patel,Sarit Balanson,Sungwoo Ryoo,Mirinda Anderson,Kaikobad Irani,Firdous A. Khanday,Luigi Di Costanzo,Daniel Nyhan,Joshua M. Hare,David W. Christianson,Richard J. Rivers,Artin A. Shoukas,Dan E. Berkowitz +18 more
TL;DR: It is suggested that S-nitrosylated arginase1 can compete with NOS for l-arginine and contribute to endothelial dysfunction in the aging cardiovascular system.