Lana Bozulic

TL;DR: This work reports a route by which activated PKB promotes survival in response to DNA insults in vivo, and places PKB downstream of DNA-PK in the DNA damage response signaling cascade, where it provides a prosurvival signal.

TL;DR: The remarkable complexity in the regulation of PKB signaling downstream of PI3K could be attributed to the specific roles of the PKB isoforms, their expression pattern, subcellular localization, targets, phosphorylation by upstream kinases in a stimulus- and context-dependent manner and by phosphatases, and interaction with binding partners.

TL;DR: PKB regulation by mTORC2 and DNA-PK in a stimulus-dependent and context-dependent manner and the possible implications of this for PKB activity, substrate specificity and therapeutic intervention are reviewed.

TL;DR: It is revealed that DNA-PK is required for DNA damage-induced phosphorylation but dispensable for insulin- and growth factor-induced PKB Ser-473 phosphorylated, and genetic evidence of PKB deregulation in DNA- PKcs-/- mice is provided.

TL;DR: The Carboxy-Terminal Modulator Protein (CTMP) protein was identified as a PKB inhibitor that binds to its hydrophobic motif as mentioned in this paper, and it exhibits a dual sub-mitochondrial localization as a membrane bound pool and a free pool of mature CTMP in the inter-membrane space.