L
Lara Compton
Researcher at University of California, Davis
Publications - 7
Citations - 848
Lara Compton is an academic researcher from University of California, Davis. The author has contributed to research in topics: Simian immunodeficiency virus & Virus. The author has an hindex of 5, co-authored 6 publications receiving 834 citations. Previous affiliations of Lara Compton include California National Primate Research Center.
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Journal ArticleDOI
Propagation and Dissemination of Infection after Vaginal Transmission of Simian Immunodeficiency Virus
Christopher J. Miller,Qingsheng Li,Kristina Abel,Eun Young Kim,Zhong-Min Ma,Stephen W. Wietgrefe,Lisa La Franco-Scheuch,Lara Compton,Lijie Duan,Marta Dykhuizen Shore,Mary Zupancic,Marc Busch,John V. Carlis,Steven Wolinksy,Ashley T. Haase +14 more
TL;DR: It is shown that the mucosal barrier greatly limits the infection of cervicovaginal tissues, and thus the initial founder populations of infected cells are small, and that continuous seeding from an expanding source of production at the portal of entry is likely critical for the later establishment of a productive infection throughout the systemic LTs.
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CD8+ T-Lymphocyte Response to Major Immunodominant Epitopes after Vaginal Exposure to Simian Immunodeficiency Virus: Too Late and Too Little
Matthew R. Reynolds,Eva G. Rakasz,Pamela J. Skinner,Cara White,Kristina Abel,Zhong-Min Ma,Lara Compton,Gnankang Napoé,Nancy A. Wilson,Christopher J. Miller,Ashley T. Haase,David I. Watkins +11 more
TL;DR: The robust response in female reproductive tissues may be an encouraging sign that vaccines that rapidly induce high-frequency CD8+ T-lymphocyte responses might be able to prevent acquisition of HIV-1 infection by the most common route of transmission.
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Simian-Human Immunodeficiency Virus SHIV89.6-Induced Protection against Intravaginal Challenge with Pathogenic SIVmac239 Is Independent of the Route of Immunization and Is Associated with a Combination of Cytotoxic T-Lymphocyte and Alpha Interferon Responses
Kristina Abel,Lara Compton,Lara Compton,Tracy Rourke,Tracy Rourke,David C. Montefiori,Ding Lu,Ding Lu,Kristina Rothaeusler,Linda Fritts,Linda Fritts,Kristen Bost,Christopher J. Miller,Christopher J. Miller +13 more
TL;DR: Attenuated primate lentivirus vaccines provide the most consistent protection against challenge with pathogenic simian immunodeficiency virus (SIV) and provide an excellent model to examine the influence of the route of immunization on challenge outcome and to study vaccine-induced protective anti-SIV immune responses.
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Protection against Simian Immunodeficiency Virus Vaginal Challenge by Using Sabin Poliovirus Vectors
Shane Crotty,Christopher J. Miller,Barbara L. Lohman,Martha R. Neagu,Lara Compton,Ding Lu,Fabien X.-S. Lü,Linda Fritts,Jeffrey D. Lifson,Raul Andino +9 more
TL;DR: The results demonstrate the efficacy of SabRV as a potential human vaccine vector, and they show that the use of a vaccine vector cocktail expressing an array of defined antigenic sequences can be an effective vaccination strategy in an outbred population.
Journal ArticleDOI
Incomplete protection against simian immunodeficiency virus vaginal transmission in rhesus macaques by a topical antiviral agent revealed by repeat challenges.
Zandrea Ambrose,Lara Compton,Michael Piatak,Ding Lu,W. Gregory Alvord,Mariusz S. Lubomirski,James E. K. Hildreth,Jeffrey D. Lifson,Christopher J. Miller,Vineet N. KewalRamani +9 more
TL;DR: In this article, 2-Hydroxypropyl-β-cyclodextrin (BCD) was shown to prevent HIV-1 and SIV infection of target cells at subtoxic doses in vitro.