L
Lara Derycke
Researcher at Ghent University Hospital
Publications - 52
Citations - 2480
Lara Derycke is an academic researcher from Ghent University Hospital. The author has contributed to research in topics: Nasal polyps & Cadherin. The author has an hindex of 25, co-authored 50 publications receiving 2139 citations. Previous affiliations of Lara Derycke include Ghent University.
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Journal ArticleDOI
N-cadherin in the spotlight of cell-cell adhesion, differentiation, embryogenesis, invasion and signalling
Lara Derycke,Marc Bracke +1 more
TL;DR: N-cadherin can have multiple functions: promoting adhesion or induction of migration dependent on the cellular context, which in some cancers, like osteosarcoma, may behave as a tumour suppressor.
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TGF-β signaling and collagen deposition in chronic rhinosinusitis
Nicholas Van Bruaene,Lara Derycke,Claudina Perez-Novo,Philippe Gevaert,Gabriele Holtappels,Natalie De Ruyck,Claude Cuvelier,Paul Van Cauwenberge,Claus Bachert +8 more
TL;DR: These findings are compatible with the remodeling patterns observed, reflected by a lack of collagen in CRSwNP, and excessive collagen production with thickening of the collagen fibers in the extracellular matrix in C RSsNP.
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Alternatively activated macrophages and impaired phagocytosis of S. aureus in chronic rhinosinusitis
Olga Krysko,Gabriele Holtappels,Nan Zhang,Malgorzata Kubica,Kim Deswarte,Lara Derycke,Sofie Claeys,Hamida Hammad,Guy Brusselle,Peter Vandenabeele,Dmitri V. Krysko,Claus Bachert +11 more
TL;DR: This data indicates that either activated macrophages and impaired phagocytosis of S. aureus in chronic rhinosinusitis is associated with elevated IgE and the need for further investigation to establish a causative mechanism.
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The HMI™ module: a new tool to study the Host-Microbiota Interaction in the human gastrointestinal tract in vitro
Massimo Marzorati,Barbara Vanhoecke,Tine De Ryck,Mehdi Sadaghian Sadabad,Iris Pinheiro,Sam Possemiers,Pieter Van den Abbeele,Lara Derycke,Marc Bracke,Jan Pieters,Tom Hennebel,Hermie J. M. Harmsen,Willy Verstraete,Tom Van de Wiele +13 more
TL;DR: The HMI module offers the possibility of co-culturing a gut representative microbial community with enterocyte-like cells up to 48 h and may therefore contribute to the mechanistic understanding of host-microbiome interactions.
Journal ArticleDOI
Mixed T Helper Cell Signatures In Chronic Rhinosinusitis with and without Polyps
Lara Derycke,Stefanie Eyerich,Koen Van Crombruggen,Claudina Perez-Novo,Gabriele Holtappels,Natalie Deruyck,Philippe Gevaert,Claus Bachert +7 more
TL;DR: T cell cytokine patterns in healthy and inflamed sinonasal mucosa revealed that Th2 cells (IL-4 and IL-5 producing cells) are significantly increased in CRSwNP mucosal inflammation.