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Sam Possemiers
Researcher at Ghent University
Publications - 86
Citations - 9614
Sam Possemiers is an academic researcher from Ghent University. The author has contributed to research in topics: Gut flora & Prebiotic. The author has an hindex of 43, co-authored 84 publications receiving 8242 citations.
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Journal ArticleDOI
Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability
Patrice D. Cani,Sam Possemiers,T. Van de Wiele,Yves Guiot,Amandine Everard,O. Rottier,Lucie Geurts,Damien Naslain,Audrey M. Neyrinck,Didier M. Lambert,Giulio G. Muccioli,Nathalie M. Delzenne +11 more
TL;DR: It is found that a selective gut microbiota change controls and increases endogenous GLP-2 production, and consequently improves gut barrier functions by a GLP1-2-dependent mechanism, contributing to the improvement of Gut barrier functions during obesity and diabetes.
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Responses of Gut Microbiota and Glucose and Lipid Metabolism to Prebiotics in Genetic Obese and Diet-Induced Leptin-Resistant Mice
Amandine Everard,Vladimir Lazarevic,Muriel Derrien,Myriam Girard,Giulio M. Muccioli,Audrey M. Neyrinck,Sam Possemiers,Ann Van Holle,Patrice Francois,Willem M. de Vos,Nathalie M. Delzenne,Jacques Schrenzel,Patrice D. Cani +12 more
TL;DR: It is concluded that specific gut microbiota modulation improves glucose homeostasis, leptin sensitivity, and target enteroendocrine cell activity in obese and diabetic mice.
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Metabolic fate of polyphenols in the human superorganism
John P. M. van Duynhoven,Elaine E. Vaughan,Doris M. Jacobs,Rober A. Kemperman,Ewoud J. J. van Velzen,Gabriele Gross,Laure C. Roger,Sam Possemiers,Age K. Smilde,Joël Doré,Johan A. Westerhuis,Tom Van de Wiele +11 more
TL;DR: Bottom-up as well as top-down approaches need to be pursued to link gut microbial diversity to functionality in nutritional phenotypes and, ultimately, to bioactivity of polyphenols.
Journal ArticleDOI
Prebiotic Effects of Wheat Arabinoxylan Related to the Increase in Bifidobacteria, Roseburia and Bacteroides/Prevotella in Diet-Induced Obese Mice
Audrey M. Neyrinck,Sam Possemiers,Céline Druart,Tom Van de Wiele,Fabienne De Backer,Patrice D. Cani,Yvan Larondelle,Nathalie M. Delzenne +7 more
TL;DR: In this article, the ability of a specific concentrate of water-extractable high molecular weight arabinoxylans (AX) from wheat to modulate both the gut microbiota and lipid metabolism in high-fat (HF) diet-induced obese mice was investigated.
Journal ArticleDOI
Microbial Community Development in a Dynamic Gut Model Is Reproducible, Colon Region Specific, and Selective for Bacteroidetes and Clostridium Cluster IX
Pieter Van den Abbeele,Charlotte Grootaert,Massimo Marzorati,Sam Possemiers,Willy Verstraete,Philippe Gérard,Sylvie Rabot,Aurélia Bruneau,Sahar El Aidy,Muriel Derrien,Erwin G. Zoetendal,Michiel Kleerebezem,Hauke Smidt,Tom Van de Wiele +13 more
TL;DR: High-resolution analysis of in vitro-cultured gut microbiota offers new insight on the microbial colonization process and indicates the importance of digestive parameters that may be crucial in the development of new in vitro models.