L
Lara Lacerda
Researcher at University of London
Publications - 26
Citations - 4648
Lara Lacerda is an academic researcher from University of London. The author has contributed to research in topics: Carbon nanotube & Lipid bilayer. The author has an hindex of 19, co-authored 26 publications receiving 4434 citations. Previous affiliations of Lara Lacerda include University of Manchester & University College London.
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Journal ArticleDOI
Cellular uptake of functionalized carbon nanotubes is independent of functional group and cell type.
Kostas Kostarelos,Lara Lacerda,Giorgia Pastorin,Wei Wu,Sébastien Wieckowski,Jacqueline Luangsivilay,Sylvie Godefroy,Davide Pantarotto,Davide Pantarotto,Jean Paul Briand,Sylviane Muller,Maurizio Prato,Alberto Bianco +12 more
TL;DR: Various types of functionalized carbon nanotubes (f-CNTs) exhibit a capacity to be taken up by a wide range of cells and can intracellularly traffic through different cellular barriers.
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Tissue biodistribution and blood clearance rates of intravenously administered carbon nanotube radiotracers
Ravi Singh,Davide Pantarotto,Lara Lacerda,Giorgia Pastorin,Cédric Klumpp,Maurizio Prato,Alberto Bianco,Kostas Kostarelos +7 more
TL;DR: The pharmacokinetic parameters of i.v. administered functionalized CNT relevant for various therapeutic and diagnostic applications are described and urine excretion studies using both f-SWNT and functionalized multiwalled CNT revealed that both types ofnanotubes were excreted as intact nanotubes.
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Carbon nanotubes as nanomedicines: from toxicology to pharmacology.
TL;DR: This review brings together all the toxicological and pharmacological in vivo studies that have been carried out using carbon nanotubes, to offer the first summary of the state-of-the-art in the pharmaceutical development of carbon Nanotubes on the road to becoming viable and effective nanomedicines.
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Cell-penetrating cnts for delivery of therapeutics
TL;DR: A speculative overview of the general principles behind the mechanism of carbon nanotube penetration of the plasma membrane and a snapshot of the different therapeutic modalities based on these fascinating nanostructures that are currently being investigated are offered.
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Translocation mechanisms of chemically functionalised carbon nanotubes across plasma membranes
Lara Lacerda,Julie Russier,Giorgia Pastorin,M. Antonia Herrero,Enrica Venturelli,Hélène Dumortier,Khuloud T. Al-Jamal,Khuloud T. Al-Jamal,Maurizio Prato,Kostas Kostarelos,Alberto Bianco +10 more
TL;DR: It is evidenced that at least 30-50% of f-MWCNTs are taken up by cells through an energy-independent mechanism, which makes nanotubes loaded with therapeutic or diagnostic cargos extremely interesting as the release of active molecules directly into the cytoplasm increase their biological activity and therapeutic efficacy.