Journal ArticleDOI
Cellular uptake of functionalized carbon nanotubes is independent of functional group and cell type.
Kostas Kostarelos,Lara Lacerda,Giorgia Pastorin,Wei Wu,Sébastien Wieckowski,Jacqueline Luangsivilay,Sylvie Godefroy,Davide Pantarotto,Davide Pantarotto,Jean Paul Briand,Sylviane Muller,Maurizio Prato,Alberto Bianco +12 more
Reads0
Chats0
TLDR
Various types of functionalized carbon nanotubes (f-CNTs) exhibit a capacity to be taken up by a wide range of cells and can intracellularly traffic through different cellular barriers.Abstract:
The development of nanomaterials for biomedical and biotechnological applications is an area of research that holds great promise and intense interest1, and carbon-based nanostructures in particular, such as carbon nanotubes (CNTs), are attracting an increasing level of attention2,3. One of the key advantages that CNTs offer is the possibility of effectively crossing biological barriers, which would allow their use in the delivery of therapeutically active molecules. Our laboratories have been investigating the use of CNTs in biomedical applications, and in particular as nanovectors for therapeutic agent delivery4,5,6,7,8. The interaction between cells and CNTs is a critical issue that will determine any future biological application of such structures. Here we show that various types of functionalized carbon nanotubes (f-CNTs) exhibit a capacity to be taken up by a wide range of cells and can intracellularly traffic through different cellular barriers.read more
Citations
More filters
Journal ArticleDOI
Functionalization of Graphene: Covalent and Non-Covalent Approaches, Derivatives and Applications
Vasilios Georgakilas,Michal Otyepka,Athanasios B. Bourlinos,Vimlesh Chandra,Namdong Kim,K. Christian Kemp,Pavel Hobza,Pavel Hobza,Pavel Hobza,Radek Zboril,Kwang S. Kim +10 more
TL;DR: Approaches, Derivatives and Applications Vasilios Georgakilas,† Michal Otyepka,‡ Athanasios B. Bourlinos,† Vimlesh Chandra, Namdong Kim, K. Kim,§,⊥ Radek Zboril,*,‡ and Kwang S. Kim.
Journal ArticleDOI
Cytotoxicity of Nanoparticles
TL;DR: For nanoparticles to move into the clinical arena, it is important that nanotoxicology research uncovers and understands how these multiple factors influence the toxicity of nanoparticles so that their undesirable properties can be avoided.
Journal ArticleDOI
Carbon Nanotubes in Biology and Medicine: In vitro and in vivo Detection, Imaging and Drug Delivery
TL;DR: Carbon nanotubes exhibit many unique intrinsic physical and chemical properties and have been intensively explored for biological and biomedical applications in the past few years as mentioned in this paper, and a comprehensive review of the main results from our and other groups in this field can be found in this paper.
Journal ArticleDOI
Broad family of carbon nanoallotropes: classification, chemistry, and applications of fullerenes, carbon dots, nanotubes, graphene, nanodiamonds, and combined superstructures.
TL;DR: Applications of Fullerenes, Carbon Dots, Nanotubes, Graphene, Nanodiamonds, and Combined Superstructures.
Journal ArticleDOI
Nanoparticle-based theranostic agents
Jin Xie,Seulki Lee,Xiaoyuan Chen +2 more
TL;DR: The current article will outline the progress along this line, organized by the category of the core materials, and focus on construction strategies and will discuss the challenges and opportunities associated with this emerging technology.
References
More filters
Journal ArticleDOI
Applications of carbon nanotubes in drug delivery
TL;DR: Carbon nanotubes have emerged as a new alternative and efficient tool for transporting and translocating therapeutic molecules and hold great potential in the field of nanobiotechnology and nanomedicine.
Journal ArticleDOI
Organic functionalization of carbon nanotubes
Vasilios Georgakilas,Konstantinos Kordatos,Maurizio Prato,Dirk M. Guldi,and Michael Holzinger,Andreas Hirsch +5 more
TL;DR: The solubilization of the nanotubes generates a novel, interesting class of materials, which combines the properties of thenanotubes and the organic moiety, thus offering new opportunities for applications in materials science, including the preparation of nanocomposites.
Journal ArticleDOI
Functionalized Carbon Nanotubes for Plasmid DNA Gene Delivery
Davide Pantarotto,Davide Pantarotto,Ravi Singh,David McCarthy,Mathieu Erhardt,Jean-Paul Briand,Maurizio Prato,Kostas Kostarelos,Alberto Bianco +8 more
TL;DR: Transmission electron microscopy analysis was performed at the microscopy facility of the Institute of Biomedical Problems and was cofinanced by CNRS, R=gion Alsace, Louis Pasteur University, and the Association de la Recherche pour le Cancer.
Journal ArticleDOI
Translocation of bioactive peptides across cell membranes by carbon nanotubes
TL;DR: Functionalised carbon nanotubes are able to cross the cell membrane and to accumulate in the cytoplasm or reach the nucleus without being toxic for the cell up to 10 µM.
Journal ArticleDOI
Biomedical applications of functionalised carbon nanotubes
TL;DR: The organic functionalisation of carbon nanotubes can improve substantially their solubility and biocompatibility profile, and they hold currently strong promise as novel systems for the delivery of drugs, antigens and genes.