L
Larisa M. Haupt
Researcher at Queensland University of Technology
Publications - 185
Citations - 4157
Larisa M. Haupt is an academic researcher from Queensland University of Technology. The author has contributed to research in topics: Population & Single-nucleotide polymorphism. The author has an hindex of 27, co-authored 164 publications receiving 3391 citations. Previous affiliations of Larisa M. Haupt include Agency for Science, Technology and Research & Texas Biomedical Research Institute.
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Mitochondrial Genome Acquisition Restores Respiratory Function and Tumorigenic Potential of Cancer Cells without Mitochondrial DNA
An S. Tan,James W. Baty,Lan-Feng Dong,Ayenachew Bezawork-Geleta,Berwini Endaya,Jacob Goodwin,Martina Bajzikova,Jaromira Kovarova,Martin Peterka,Bing Yan,Elham Alizadeh Pesdar,Margarita Sobol,Anatolyj Filimonenko,Shani Stuart,Magdalena Vondrusova,Katarina Kluckova,Karishma Sachaphibulkij,Jakub Rohlena,Pavel Hozák,Jaroslav Truksa,David Eccles,Larisa M. Haupt,Lyn R. Griffiths,Jiri Neuzil,Jiri Neuzil,Michael V. Berridge +25 more
TL;DR: This paper showed that tumor cells without mitochondrial DNA (mtDNA) showed delayed tumor growth, and that tumor formation is associated with acquisition of mtDNA from host cells, leading to partial recovery of mitochondrial function in cells derived from primary tumors grown from cells without mtDNA and a shorter lag in tumor growth.
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Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes.
Serguei R. Romanov,B. Krystyna Kozakiewicz,Charles R. Holst,Martha R. Stampfer,Larisa M. Haupt,Thea D. Tlsty +5 more
TL;DR: The authors showed that human mammary epithelial cells (HMECs) do not conform to this paradigm of senescence and genomic integrity are important barriers in the development of malignant lesions.
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Locked nucleic acid (LNA) single nucleotide polymorphism (SNP) genotype analysis and validation using real‐time PCR
TL;DR: In this article, the authors used SNP specific LNA hybridization probes on a real-time PCR platform to genotype an association cohort and propose three criteria to address ambiguous genotypes.
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The osteogenic transcription factor Runx2 regulates components of the fibroblast growth factor/proteoglycan signaling axis in osteoblasts
Nadiya M. Teplyuk,Larisa M. Haupt,Ling Ling,Christian Dombrowski,Foong Kin Mun,Saminathan S. Nathan,Jane B. Lian,Janet L. Stein,Gary S. Stein,Simon M. Cool,Simon M. Cool,Andre J. van Wijnen +11 more
TL;DR: In this article, Runx2 and basic fibroblast growth factor (bFGF/FGF2) signaling is used to control osteoblast growth and differentiation, as well as metabolic functions of osteoblasts.
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Synergism between Wnt3a and Heparin Enhances Osteogenesis via a Phosphoinositide 3-Kinase/Akt/RUNX2 Pathway
Ling Ling,Christian Dombrowski,Kin Mun Foong,Larisa M. Haupt,Gary S. Stein,Victor Nurcombe,Andre J. Van Wijnen,Simon M. Cool +7 more
TL;DR: Wang et al. as discussed by the authors showed that the osteogenic activity of Wnt3a is cooperatively stimulated through physical interactions with exogenous heparin in non-osseous tissues and suggested that heparan sulfate supplementation may selectively reduce the therapeutic doses of peptide factors required to promote bone formation.