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Ayenachew Bezawork-Geleta
Researcher at Griffith University
Publications - 23
Citations - 1907
Ayenachew Bezawork-Geleta is an academic researcher from Griffith University. The author has contributed to research in topics: Mitochondrion & Cancer cell. The author has an hindex of 16, co-authored 21 publications receiving 1434 citations. Previous affiliations of Ayenachew Bezawork-Geleta include University of Melbourne & La Trobe University.
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Journal ArticleDOI
Mitochondrial Genome Acquisition Restores Respiratory Function and Tumorigenic Potential of Cancer Cells without Mitochondrial DNA
An S. Tan,James W. Baty,Lan-Feng Dong,Ayenachew Bezawork-Geleta,Berwini Endaya,Jacob Goodwin,Martina Bajzikova,Jaromira Kovarova,Martin Peterka,Bing Yan,Elham Alizadeh Pesdar,Margarita Sobol,Anatolyj Filimonenko,Shani Stuart,Magdalena Vondrusova,Katarina Kluckova,Karishma Sachaphibulkij,Jakub Rohlena,Pavel Hozák,Jaroslav Truksa,David Eccles,Larisa M. Haupt,Lyn R. Griffiths,Jiri Neuzil,Jiri Neuzil,Michael V. Berridge +25 more
TL;DR: This paper showed that tumor cells without mitochondrial DNA (mtDNA) showed delayed tumor growth, and that tumor formation is associated with acquisition of mtDNA from host cells, leading to partial recovery of mitochondrial function in cells derived from primary tumors grown from cells without mtDNA and a shorter lag in tumor growth.
Journal ArticleDOI
Horizontal transfer of whole mitochondria restores tumorigenic potential in mitochondrial DNA-deficient cancer cells.
Lan-Feng Dong,Jaromira Kovarova,Martina Bajzikova,Ayenachew Bezawork-Geleta,David Svec,Berwini Endaya,Karishma Sachaphibulkij,Ana R Coelho,Ana R Coelho,Natasa Sebkova,Natasa Sebkova,Anna Ruzickova,An S. Tan,Katarina Kluckova,Kristyna Judasova,Katerina Zamecnikova,Zuzana Rychtarcikova,Zuzana Rychtarcikova,Vinod Gopalan,Ladislav Andera,Margarita Sobol,Bing Yan,Bijay Pattnaik,Naveen Kumar Bhatraju,Jaroslav Truksa,Pavel Stopka,Pavel Hozák,Alfred King-Yin Lam,Radislav Sedlacek,Paulo J. Oliveira,Mikael Kubista,Anurag Agrawal,Katerina Dvorakova-Hortova,Katerina Dvorakova-Hortova,Jakub Rohlena,Michael V. Berridge,Jiri Neuzil,Jiri Neuzil +37 more
TL;DR: Results show that intact mitochondria with their mtDNA payload are transferred in the developing tumour, and provide functional evidence for an essential role of oxidative phosphorylation in cancer.
Journal ArticleDOI
Reactivation of Dihydroorotate Dehydrogenase-Driven Pyrimidine Biosynthesis Restores Tumor Growth of Respiration-Deficient Cancer Cells.
Martina Bajzikova,Martina Bajzikova,Jaromira Kovarova,Ana R Coelho,Ana R Coelho,Stepana Boukalova,Sehyun Oh,Katerina Rohlenova,David Svec,Sona Hubackova,Berwini Endaya,Kristyna Judasova,Ayenachew Bezawork-Geleta,Katarina Kluckova,Laurent Chatre,Laurent Chatre,Renata Zobalova,Anna Novakova,Katerina Vanova,Zuzana Ezrova,Zuzana Ezrova,Ghassan J. Maghzal,Ghassan J. Maghzal,Silvia Magalhaes Novais,Silvia Magalhaes Novais,Marie Olšinová,Linda Krobova,Yong Jin An,Eliska Davidova,Eliska Davidova,Zuzana Nahacka,Margarita Sobol,Teresa Cunha-Oliveira,Cristian Sandoval-Acuña,Hynek Strnad,Tongchuan Zhang,Thanh Huynh,Teresa L. Serafim,Pavel Hozák,Vilma A. Sardão,Werner J.H. Koopman,Miria Ricchetti,Miria Ricchetti,Paulo J. Oliveira,Frantisek Kolar,Mikael Kubista,Jaroslav Truksa,Katerina Dvorakova-Hortova,Katerina Dvorakova-Hortova,Karel Pacak,Robert Gürlich,Roland Stocker,Roland Stocker,Yaoqi Zhou,Michael V. Berridge,Sunghyouk Park,Lan-Feng Dong,Jakub Rohlena,Jiri Neuzil,Jiri Neuzil +59 more
TL;DR: It is shown that pyrimidine biosynthesis dependent on respiration-linked dihydroorotate dehydrogenase (DHODH) is required to overcome cell-cycle arrest, while mitochondrial ATP generation is dispensable for tumorigenesis, pointing to inhibitors of DHODH as potential anti-cancer agents.
Journal ArticleDOI
Mitochondrial Complex II: At the Crossroads
TL;DR: Recent findings regarding SDH biogenesis are discussed, and the emerging role of both genetic and epigenetic aberrations leading to SDH dysfunction associated with various clinical manifestations are focused on.
Journal ArticleDOI
AtnMat2, a nuclear-encoded maturase required for splicing of group-II introns in Arabidopsis mitochondria.
Ido Keren,Ayenachew Bezawork-Geleta,Max Kolton,Inbar Maayan,Eduard Belausov,Maggie Levy,Anahit Mett,David Gidoni,Felix Shaya,Oren Ostersetzer-Biran +9 more
TL;DR: Intriguingly, higher plants genomes contain four maturase-related genes, which exist in the nucleus as self-standing ORFs, out of the context of their evolutionary-related group-II introns "hosts." These are all predicted to reside within mitochondria and may therefore act "in-trans" in the splicing of organellar-encoded introns.