Larissa Lezina

TL;DR: Lysine-specific demethylase 1 regulates the expression and appropriate timing of key developmental regulators, as part of the LSD1/CoREST/HDAC complex, during early embryonic development.

TL;DR: The results could facilitate the study of senescence, define potential new effectors and modulators of this cellular mechanism and provide potential diagnostic and prognostic tools to be used clinically.

TL;DR: This approach can provide a plausible alternative to conventional antibodies and sets up a new paradigm for the therapeutic application of this class of materials against clinically relevant targets, and nanoMIPs can promote the development of cell imaging tools against difficult targets such as membrane proteins.

TL;DR: The bioinformatics analysis of survival times for patients with breast and prostate cancers has revealed that co-expression of mir-16 and miR-26a correlated with a better survival outcome, and provides a novel mechanism whereby p53 represses Chk1 and Wee1 expression, at least partially, via upregulation of miRs and thus sensitizes tumour cells to genotoxic therapies.

TL;DR: A novel role for CLL-EVs in modifying T- cell function that highlights unanticipated complexity of intercellular communication that may have implications for bidirectional CD4(+) T-cell:tumor interactions within the TME is revealed.