L
Larry A. Walker
Researcher at University of Mississippi
Publications - 14
Citations - 313
Larry A. Walker is an academic researcher from University of Mississippi. The author has contributed to research in topics: Flavanone & Cytotoxicity. The author has an hindex of 8, co-authored 14 publications receiving 296 citations. Previous affiliations of Larry A. Walker include St. Jude Children's Research Hospital & Georgetown University.
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Journal ArticleDOI
Automated high-throughput system to fractionate plant natural products for drug discovery.
Ying Tu,Cynthia Jeffries,Hong Ruan,Cynthia Nelson,David C. Smithson,Anang A. Shelat,Kristin M. Brown,Xing-Cong Li,John P. Hester,Troy A. Smillie,Ikhlas A. Khan,Larry A. Walker,Kip Guy,Bing Yan +13 more
TL;DR: This procedure modernizes the traditional natural product fractionation paradigm by seamlessly integrating automation, informatics, and multimodal analytical interrogation capabilities.
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New Acylphloroglucinol Derivatives with Diverse Architectures from Hypericum henryi
Xing-Wei Yang,Yuanqing Ding,Jing-Jing Zhang,Xia Liu,Li-Xin Yang,Xiao-Nian Li,Daneel Ferreira,Larry A. Walker,Gang Xu +8 more
TL;DR: Hyphenrones A-F (1-6), six polycyclic polyprenylated acylphloroglucinol derivatives with four architectures including three unprecedented cores as exemplified by 1, 3, and 4, were isolated from Hypericum henryi and exhibited interesting AChE inhibitory activities.
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Absolute configuration, conformation, and chiral properties of flavanone-(3→8″)-flavone biflavonoids from Rheedia acuminata
Xing-Cong Li,Alpana S. Joshi,Bo Tan,Hala N. ElSohly,Larry A. Walker,Jordan K. Zjawiony,Daneel Ferreira +6 more
TL;DR: In this paper, the absolute configurations of three flavanone-(3→8″)-flavone type biflavonoids, (+)-morelloflavone (1), (+)-volkensiflavone-7-sulfate (2 ), isolated from Rheedia acuminata, were confirmed by circular dichroism as 2 R,3 S, hence clarifying the literature confusion of 2 S,3 R absolute configuration for (+-morelloftlavone.
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Flavanone glycosides from Miconia trailii.
Zhizhen Zhang,Hala N. Elsohly,Xing-Cong Li,Shabana I. Khan,Sheldon E. Broedel,Robert E. Raulli,Ronald L. Cihlar,Larry A. Walker +7 more
TL;DR: Assay-guided fractionation of the ethanol extract of the twigs and leaves of Miconia trailii yielded two new flavanone glycosides, matteucinol and farrerol, and the structures of 1-8 were elucidated by spectroscopic methods, including 2D NMR.
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Enantioselective synthesis and complement inhibitory assay of A/B-ring partial analogues of oleanolic acid.
TL;DR: A series of oleanolic acid A/B-ring partial analogues was synthesized and tested for their complement inhibitory activity as well as cytotoxic properties and all target compounds and one intermediate exhibited moderate complement inhibitors potency.