L
Larysa H. Pevny
Researcher at University of North Carolina at Chapel Hill
Publications - 49
Citations - 11172
Larysa H. Pevny is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Neural stem cell & Stem cell. The author has an hindex of 33, co-authored 49 publications receiving 10389 citations. Previous affiliations of Larysa H. Pevny include National Institute for Medical Research.
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Multipotent cell lineages in early mouse development depend on SOX2 function
Ariel A. Avilion,Silvia K. Nicolis,Larysa H. Pevny,Lidia Pérez,Nigel Vivian,Robin Lovell-Badge +5 more
TL;DR: The data suggest that maternal components could be involved in establishing early cell fate decisions and that a combinatorial code, requiring SOX2 and OCT4, specifies the first three lineages present at implantation.
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SOX2 Functions to Maintain Neural Progenitor Identity
TL;DR: It is shown here that constitutive expression of SOX2 inhibits neuronal differentiation and results in the maintenance of progenitor characteristics, and that SOXB1 signaling is both necessary and sufficient to maintain panneural properties of neural progenitors.
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SOX2, a Persistent Marker for Multipotential Neural Stem Cells Derived from Embryonic Stem Cells, the Embryo or the Adult
Pam Ellis,B. Matthew Fagan,Scott T. Magness,Scott R. Hutton,Olena Taranova,Shigemi Hayashi,Andrew P. McMahon,Mahendra S. Rao,Larysa H. Pevny +8 more
TL;DR: It is demonstrated that SOX2 may meet the requirements of a universal neural stem cell marker and provides a means to identify cells which fulfill the basic criteria of a stem cell: self-renewal and multipotent differentiation.
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SOX2 is a dose-dependent regulator of retinal neural progenitor competence
Olena Taranova,Scott T. Magness,B. Matthew Fagan,Yongqin Wu,Natalie Surzenko,Scott R. Hutton,Larysa H. Pevny +6 more
TL;DR: Results show that precise regulation of SOX2 dosage is critical for temporal and spatial regulation of retinal progenitor cell differentiation and provide a cellular and molecular model for understanding how hypomorphic levels ofSOX2 cause retinal defects in humans.
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Generation of purified neural precursors from embryonic stem cells by lineage selection
TL;DR: It is reported that application of lineage-restricted precursors from differentiating populations enables efficient purification of neuroepithelial progenitor cells that subsequently differentiate efficiently into neuronal networks in the absence of other cell types.