L
Luigi F. Agnati
Researcher at Karolinska Institutet
Publications - 336
Citations - 17917
Luigi F. Agnati is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Receptor & Dopamine. The author has an hindex of 67, co-authored 329 publications receiving 17049 citations. Previous affiliations of Luigi F. Agnati include University of Modena and Reggio Emilia & University of Milan.
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Journal ArticleDOI
Intercellular communication in the brain: wiring versus volume transmission.
TL;DR: The basic definitions and some distinctive characteristics of the two types of transmission are discussed and the evidence for different types of intercellular communication besides synaptic transmission in the central nervous system during phylogeny, and in vertebrates in physiological and pathological conditions is reviewed.
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Mapping of glucocorticoid receptor immunoreactive neurons in the rat tel- and diencephalon using a monoclonal antibody against rat liver glucocorticoid receptor.
Kjell Fuxe,Ann-Charlotte Wikström,Sam Okret,Luigi F. Agnati,Anders Härfstrand,Zhao-Ying Yu,Lars Granholm,Michaeli Zoli,Wylie Vale,Jan-Åke Gustafsson +9 more
TL;DR: It is suggested that the hypothalamic GR may be involved in the regulation of especially CRF secretion but also in the secretion of other anterior pituitary hormones such as TRH and somatostatin.
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Coaggregation, cointernalization, and codesensitization of adenosine A2A receptors and dopamine D2 receptors
Joëlle Hillion,Meritxell Canals,Maria Torvinen,Vicent Casadó,Rizaldy P. Scott,Anton Terasmaa,Anita C. Hansson,Stanley Watson,Mark E. Olah,Josefa Mallol,Enric I. Canela,Michele Zoli,Luigi F. Agnati,Carlos F. Ibáñez,Carme Lluís,Rafael Franco,Sergi Ferré,Sergi Ferré,Kjell Fuxe +18 more
TL;DR: The results give a molecular basis for adenosine-dopamine antagonism at the membrane level and have implications for treatment of Parkinson's disease and schizophrenia, in which D2R are involved.
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Dopamine D1 and adenosine A1 receptors form functionally interacting heteromeric complexes
Silvia Ginés,Joëlle Hillion,Maria Torvinen,Stéphane Le Crom,Vicent Casadó,Enric I. Canela,Sofia Rondin,J.Y. Lew,Stanley J. Watson,Michele Zoli,Luigi F. Agnati,Philippe Vernier,Carmen Lluis,Sergi Ferré,Kjell Fuxe,Rafael Franco +15 more
TL;DR: The A(1)R/D( 1)R heteromerization may be one molecular basis for the demonstrated antagonistic modulation of A(2)R of D(1]R receptor signaling in the brain and seems to be essential for the blockade of A-1-R agonist-induced A(3)R-induced coclustering and for the desensitization of the D(0)R agonists cAMP accumulation.
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Molecular Mechanisms and Therapeutical Implications of Intramembrane Receptor/Receptor Interactions among Heptahelical Receptors with Examples from the Striatopallidal GABA Neurons
TL;DR: The molecular basis for the known intramembrane receptor/receptor interactions among G protein-coupled receptors was postulated to be heteromerization based on receptor subtype-specific interactions between different types of receptor homomers, and the discovery of GABAB heterodimers started this field rapidly.