Laura González-Silva

TL;DR: Once applied to clinical samples across tumor types, single-cell sequencing technologies could trigger an exponential increase in knowledge of the molecular pathways involved in cancer progression and contribute to the improvement of cancer treatment.

TL;DR: The molecular cause of the sex reversal was the failure of Gadd45g−/− XY gonads to achieve the SRY expression threshold necessary for testes differentiation, resulting in ovary and Müllerian duct development.

TL;DR: The authors present standardized computational pipelines tailored specifically to the analysis of cancer genome sequencing data from mice, which enables detection of single-nucleotide variants, indels, copy-number variations, loss of heterozygosity and complex rearrangements such as those of chromothripsis.

TL;DR: Identical twins with concordant BCP-ALL have provided a unique and tractable model to delineate the natural history and clonal evolution of the disease.

TL;DR: In this article, the authors performed targeted sequencing of a cohort of lung cancer patients on genes involved in chromatin structure and found that 20% of these patients showed ARID2 protein loss.