J
Juana M. Flores
Researcher at Complutense University of Madrid
Publications - 188
Citations - 13354
Juana M. Flores is an academic researcher from Complutense University of Madrid. The author has contributed to research in topics: Telomere & Telomerase. The author has an hindex of 54, co-authored 179 publications receiving 12261 citations. Previous affiliations of Juana M. Flores include National University of San Marcos & Interactive Intelligence.
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Tumour biology: Senescence in premalignant tumours
Manuel Collado,Jesús Gil,Alejo Efeyan,Carmen Guerra,Alberto J. Schuhmacher,Marta Barradas,Alberto Benguria,Ángel Zaballos,Juana M. Flores,Mariano Barbacid,David Beach,Manuel Serrano +11 more
TL;DR: It is shown that senescent cells exist in premalignant tumours but not in malignant ones, and that senescence is therefore a defining feature of premalign tumours that could prove valuable in the diagnosis and prognosis of cancer.
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The Signaling Adaptor p62 Is an Important NF-κB Mediator in Tumorigenesis
Angeles Duran,Juan F. Linares,Anita Gálvez,Kathryn Wikenheiser,Juana M. Flores,Maria T. Diaz-Meco,Jorge Moscat +6 more
TL;DR: In this paper, the authors show that the signaling adaptor p62 is induced by Ras, its levels are increased in human tumors, and it is required for Ras-induced survival and transformation.
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"Super p53" mice exhibit enhanced DNA damage response, are tumor resistant and age normally.
Isabel Garcia-Cao,Marta García-Cao,Juan Martín-Caballero,Luis M. Criado,Peter Klatt,Juana M. Flores,Jean-Claude Weill,Maria A. Blasco,Manuel Serrano +8 more
TL;DR: The generation and characterization of mice carrying supernumerary copies of the p53 gene in the form of large genomic transgenes are reported, proving that cancer resistance can be enhanced by a simple genetic modification and in the absence of undesirable effects.
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Disease states associated with telomerase deficiency appear earlier in mice with short telomeres
Eloisa Herrera,Enrique Samper,Juan Martín-Caballero,Juana M. Flores,Han Woong Lee,Maria A. Blasco +5 more
TL;DR: Results indicate that telomere shortening in mTR−/− mice leads to progressive loss of organismal viability.
Journal ArticleDOI
Delayed ageing through damage protection by the Arf/p53 pathway
Ander Matheu,Antonio Maraver,Peter Klatt,Ignacio Flores,Isabel Garcia-Cao,Consuelo Borrás,Consuelo Borrás,Juana M. Flores,Jose Viña,Maria A. Blasco,Manuel Serrano +10 more
TL;DR: It is shown that genetically manipulated mice with increased, but otherwise normally regulated, levels of Arf and p53 present strong cancer resistance and have decreased levels of ageing-associated damage, revealing a previously unknown anti-ageing mechanism and providing a rationale for the co-evolution ofcancer resistance and longevity.