L
Laura Vainio
Researcher at University of Oulu
Publications - 11
Citations - 372
Laura Vainio is an academic researcher from University of Oulu. The author has contributed to research in topics: Cardiac function curve & Myocardial infarction. The author has an hindex of 8, co-authored 10 publications receiving 276 citations.
Papers
More filters
Journal ArticleDOI
Characterization of apela, a novel endogenous ligand of apelin receptor, in the adult heart
Ábel Perjés,Ábel Perjés,Teemu Kilpiö,Johanna Ulvila,Johanna Magga,Tarja Alakoski,Zoltan Szabo,Laura Vainio,Eveliina Halmetoja,Olli Vuolteenaho,Ulla E. Petäjä-Repo,Ulla E. Petäjä-Repo,István Szokodi,Risto Kerkelä,Risto Kerkelä +14 more
TL;DR: It is concluded that apela is present in the adult heart, is upregulated in post-infarction cardiac remodeling, and increases cardiac contractility in an ERK1/2-dependent manner.
Journal ArticleDOI
Connective Tissue Growth Factor Inhibition Attenuates Left Ventricular Remodeling and Dysfunction in Pressure Overload–Induced Heart Failure
Zoltan Szabo,Johanna Magga,Tarja Alakoski,Johanna Ulvila,Jarkko Piuhola,Laura Vainio,Kari I. Kivirikko,Olli Vuolteenaho,Heikki Ruskoaho,Kenneth E. Lipson,Pierre E. Signore,Risto Kerkelä +11 more
TL;DR: CTGF mAb protects from adverse LV remodeling and LV dysfunction in hearts subjected to pressure overload by TAC, and antagonizing the function of CTGF may offer protection from cardiac end-organ damage in patients with hypertension.
Journal ArticleDOI
Inhibition of Let-7 microRNA attenuates myocardial remodeling and improves cardiac function postinfarction in mice
Anna-Maria Tolonen,Johanna Magga,Zoltan Szabo,Pirkko Viitala,Ehre Gao,Anne-Mari Moilanen,Pauli Ohukainen,Laura Vainio,Walter J. Koch,Risto Kerkelä,Heikki Ruskoaho,Heikki Ruskoaho,Raisa Serpi +12 more
TL;DR: In conclusion, inhibition of Let‐7 miRNA may be beneficial for the prevention of postinfarction LV remodeling and progression of heart failure.
Journal ArticleDOI
Activation of Hypoxia Response in Endothelial Cells Contributes to Ischemic Cardioprotection
Risto Kerkelä,Sara Karsikas,Zoltan Szabo,Raisa Serpi,Johanna Magga,Erhe Gao,Kari Alitalo,Andrey Anisimov,Raija Sormunen,Ilkka Pietilä,Laura Vainio,Walter J. Koch,Kari I. Kivirikko,Johanna Myllyharju,Peppi Koivunen +14 more
TL;DR: Activation of the hypoxia response by Hif-P4H-2 inhibition in endothelial cells appears to be a major determinant of ischemic cardioprotection and justifies the exploration of systemic small-molecule HIF-P 4H- 2 inhibitors for isChemic heart disease.
Journal ArticleDOI
Connective Tissue Growth Factor Inhibition Enhances Cardiac Repair and Limits Fibrosis After Myocardial Infarction
Laura Vainio,Zoltan Szabo,Ruizhu Lin,Johanna Ulvila,Raisa Yrjölä,Tarja Alakoski,Jarkko Piuhola,Walter J. Koch,Heikki Ruskoaho,Shaun D. Fouse,Todd W. Seeley,Erhe Gao,Pierre E. Signore,Kenneth E. Lipson,Johanna Magga,Risto Kerkelä,Risto Kerkelä +16 more
TL;DR: In this paper, the authors showed that CTGF mAb therapy during infarct repair improved survival and reduced LV dysfunction, and reduced post-MI hypertrophy and fibrosis.