Peppi Koivunen

TL;DR: The authors show that the PHD1 controls muscle mass in a hydroxylation-independent manner and prevents the degradation of leucine sensor LRS during oxygen and amino acid depletion to ensure effective mTORC1 activation in response to leucines.

TL;DR: It is found that the longest and shortest isoenzymes have major transcripts encoding inactive polypeptides, which suggest novel regulation by alternative splicing, and it should be possible to develop specific inhibitors for each class of P4Hs and possibly even for the individual HIF-P 4Hs.

TL;DR: Findings define an enantiomer-specific mechanism by which the (R)-2HG that accumulates in IDH mutant brain tumours promotes transformation and provide a justification for exploring EGLN inhibition as a potential treatment strategy.

TL;DR: It is shown that a canonical IDH 1 mutant, IDH1 R132H, promotes cytokine independence and blocks differentiation in hematopoietic cells, and that transformation by (R)-2HG is reversible.

TL;DR: The data indicate that the transcriptional activity of HIF is quite high even when binding of the coactivator p300 is prevented, and support recent suggestions that the increased fumarate and succinate levels present in the FH and succinated dehydrogenase-deficient tumors, respectively, can inhibit the HIF-P4Hs with consequent stabilization of Hif-αs and effects on tumor pathology.