L
Laureano Bragado
Researcher at Facultad de Ciencias Exactas y Naturales
Publications - 6
Citations - 81
Laureano Bragado is an academic researcher from Facultad de Ciencias Exactas y Naturales. The author has contributed to research in topics: Gene & RNA splicing. The author has an hindex of 3, co-authored 3 publications receiving 42 citations. Previous affiliations of Laureano Bragado include University of Buenos Aires.
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Journal ArticleDOI
SUMO conjugation to spliceosomal proteins is required for efficient pre-mRNA splicing.
Berta Pozzi,Berta Pozzi,Laureano Bragado,Laureano Bragado,Cindy L. Will,Pablo Mammi,Pablo Mammi,Guillermo Risso,Guillermo Risso,Henning Urlaub,Reinhard Lührmann,Anabella Srebrow,Anabella Srebrow +12 more
TL;DR: It is shown here that addition of a recombinant SUMO-protease decreases the efficiency of pre-mRNA splicing in vitro and indicates that SUMO conjugation plays a role during the splicing process and suggest the involvement of Prp3 SUMOylation in U4/U6•U5 tri-snRNP formation and/or recruitment.
Journal ArticleDOI
Dengue virus targets RBM10 deregulating host cell splicing and innate immune response
Berta Pozzi,Berta Pozzi,Laureano Bragado,Laureano Bragado,Pablo Mammi,Pablo Mammi,Maria Florencia Torti,Maria Florencia Torti,Nicolás Gaioli,Nicolás Gaioli,Leopoldo German Gebhard,Martín E García Solá,Martín E García Solá,Rita Vaz-Drago,Nestor Gabriel Iglesias,Cybele C. García,Cybele C. García,Andrea V. Gamarnik,Anabella Srebrow,Anabella Srebrow +19 more
TL;DR: It is proposed RBM10 fulfills diverse pro-inflammatory, anti-viral tasks, besides its well-documented role in splicing regulation of apoptotic genes, and interacts with viral RNA and RIG-I, and even promotes the ubiquitination of the latter, a crucial step for its activation.
Journal ArticleDOI
When SUMO met splicing
TL;DR: It is posited that SUMO conjugation could represent a way of modulating spliceosome assembly and thus, splicing efficiency and how cycles of SUMOylation/de-SUMOylations of splicedosomal proteins become integrated throughout the highly choreographed spliceOSomal cycle awaits further investigation.
Journal ArticleDOI
SUMO conjugation regulates the activity of the Integrator complex
Laureano Bragado,Melina Magalnik,Pablo Mammi,Agustín Romero,Nicolás Gaioli,Berta Pozzi,Anabella Srebrow +6 more
TL;DR: The findings point to a regulatory role of SUMO conjugation on Integrator activity and suggest the involvement of INTS11 SUMOylation in the assembly of the complex, which adds the Integrator-dependent RNA processing to the growing list of cellular processes regulated by SUMO Conjugation.
Posted ContentDOI
Influence of circular RNA topology on microRNA stability
Federico Fuchs Wightman,Jeronimo Lukin,Sebastian A. Giusti,Michael Soutschek,Laureano Bragado,Berta Pozzi,Paula González,Juan Pablo Fededa,Gerhard Schratt,Damian Refojo,Manuel L. de la Mata +10 more
TL;DR: It is shown that RNA topology seems critical for TDMD, and a model in which circRNAs lead to a topology-dependent TDMD evasion, aiding in the stabilization of specific microRNAs is supported.