D
Damian Refojo
Researcher at Max Planck Society
Publications - 56
Citations - 4200
Damian Refojo is an academic researcher from Max Planck Society. The author has contributed to research in topics: Corticotropin-releasing hormone & Receptor. The author has an hindex of 24, co-authored 53 publications receiving 3466 citations. Previous affiliations of Damian Refojo include Facultad de Ciencias Exactas y Naturales.
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Journal ArticleDOI
Circular RNAs in the Mammalian Brain Are Highly Abundant, Conserved, and Dynamically Expressed
Agnieszka Rybak-Wolf,Christin Stottmeister,Petar Glažar,Marvin Jens,Natalia S. Pino,Sebastian A. Giusti,Mor Hanan,Mikaela Behm,Osnat Bartok,Reut Ashwal-Fluss,Margareta Herzog,Luisa Schreyer,Panagiotis Papavasileiou,Andranik Ivanov,Marie Öhman,Damian Refojo,Sebastian Kadener,Nikolaus Rajewsky +17 more
TL;DR: A circRNA brain expression atlas and evidence for important circRNA functions and values as biomarkers are provided and discovered and analyzed thousands of neuronal human and mouse circRNAs.
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Glutamatergic and Dopaminergic Neurons Mediate Anxiogenic and Anxiolytic Effects of CRHR1
Damian Refojo,Martin C. Schweizer,Claudia Kuehne,Stefanie Ehrenberg,Christoph K. Thoeringer,Annette M. Vogl,Nina Dedic,Marion Schumacher,Gregor von Wolff,Charilaos Avrabos,Chadi Touma,David Engblom,Günther Schütz,Klaus-Armin Nave,Matthias Eder,Carsten T. Wotjak,Inge Sillaber,Florian Holsboer,Wolfgang Wurst,Jan M. Deussing +19 more
TL;DR: A bidirectional model for the role of CRHR1 in anxiety is defined and it is suggested that an imbalance betweenCRHR1-controlled anxiogenic glutamatergic and anxiolytic dopaminergic systems might lead to emotional disorders.
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Activation and Induction of NUR77/NURR1 in Corticotrophs by CRH/cAMP: Involvement of Calcium, Protein Kinase A, and MAPK Pathways
Damián Kovalovsky,Damian Refojo,Ana C. Liberman,Daniel Hochbaum,Marcelo Paez Pereda,Omar A Coso,Günter K. Stalla,Florian Holsboer,Eduardo Arzt +8 more
TL;DR: In AtT-20 corticotrophs the CRH/cAMP signaling that leads to Nur77/Nurr1 mRNA induction and transcriptional activation, and thus POMC expression, is dependent on protein kinase A and involves calcium/calmodulin kinase II (Nur induction/activation) and MAPK calcium-dependent and -independent pathways.
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Involvement of bone morphogenetic protein 4 (BMP-4) in pituitary prolactinoma pathogenesis through a Smad/estrogen receptor crosstalk
Marcelo Paez-Pereda,Damiana Giacomini,Damian Refojo,Alberto Carbia Nagashima,U. Hopfner,Yvonne Grübler,A. Chervin,V. Goldberg,Rodolfo G. Goya,Shane T. Hentges,Malcolm J. Low,Florian Holsboer,Günter K. Stalla,Eduardo Arzt +13 more
TL;DR: The bone morphogenetic protein (BMP) inhibitor noggin is down-regulated in prolactinomas from dopamine D2-receptor-deficient mice, proving that BMP-4/Smad4 are involved in tumor development in vivo.
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Conditional mouse mutants highlight mechanisms of corticotropin-releasing hormone effects on stress-coping behavior
Ailing Lu,M. A. Steiner,Nigel Whittle,Annette M. Vogl,S. M. Walser,M Ableitner,Damian Refojo,Marc Ekker,John L.R. Rubenstein,Günter K. Stalla,Nicolas Singewald,Florian Holsboer,Carsten T. Wotjak,Wolfgang Wurst,Jan M. Deussing +14 more
TL;DR: Enhanced noradrenergic activity was identified as potential molecular mechanism underlying increased active stress-coping behavior observed in these animals and may serve as animal models for stress-elicited pathologies and treatments that target the central CRH system.