Laurel E. Hind

TL;DR: This review discusses neutrophil polarization and plasticity and the function of proinflammatory/anti-inflammatory and protumor/antitumor neutrophils in the tumor microenvironment and how neutrophIL with the ability to suppress T-cell activation fit into this paradigm.

TL;DR: Cell intrinsic mechanisms that regulate neutrophil polarization and motility are discussed, with a focus on the uropod, and how relationships among regulatory mechanisms change when cells change their direction of migration is examined.

TL;DR: These findings identify distinct receptors that mediate bidirectional leukocyte motility during interstitial migration depending on the context and type of tissue damage in vivo.

TL;DR: The first traction maps of motile primary human macrophage migration by observing their migration on compliant polyacrylamide gels are created and it is found that the force generated by migrating macrophages is concentrated in the leading edge of the cell - so-called frontal towing and that the magnitude of this force is dependent on the stiffness of the underlying matrix.

TL;DR: The motility and force generation of primary human macrophages polarized down the M1 and M2 pathways is investigated using chemokinesis assays and traction force microscopy on polyacrylamide gels and it is found that M1macrophages are significantly less motile and M1 macrophage are significantly more motile than unactivated M0 Macrophages.