L
Lauren D. Black
Researcher at Tufts University
Publications - 72
Citations - 5336
Lauren D. Black is an academic researcher from Tufts University. The author has contributed to research in topics: Extracellular matrix & Tissue engineering. The author has an hindex of 27, co-authored 67 publications receiving 4514 citations. Previous affiliations of Lauren D. Black include University of Minnesota & Tufts Medical Center.
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Journal ArticleDOI
Perfusion-decellularized matrix: using nature's platform to engineer a bioartificial heart
Harald C. Ott,Thomas S Matthiesen,Saik Kia Goh,Lauren D. Black,Stefan M. Kren,Theoden I. Netoff,Doris A. Taylor +6 more
TL;DR: Eight constructs decellularized hearts by coronary perfusion with detergents, preserved the underlying extracellular matrix, and produced an acellular, perfusable vascular architecture, competent a cellular valves and intact chamber geometry that could generate pump function in a modified working heart preparation.
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Electrical and mechanical stimulation of cardiac cells and tissue constructs.
TL;DR: The biological underpinnings of both mechanical and electrical signaling, as identified via studies related to cardiac development and those related to an evaluation of cardiac disease progression are sought, as well as the development of bioreactors that combine electrical and mechanical stimulation in order to mimic the complex signaling environment present in vivo.
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In vitro and in vivo analysis of visible light crosslinkable gelatin methacryloyl (GelMA) hydrogels
Iman Noshadi,Iman Noshadi,Seonki Hong,Seonki Hong,Seonki Hong,Kelly E. Sullivan,Ehsan Shirzaei Sani,Roberto Portillo-Lara,Ali Tamayol,Ali Tamayol,Ali Tamayol,Su Ryon Shin,Su Ryon Shin,Albert Eric Gao,Whitney L. Stoppel,Lauren D. Black,Ali Khademhosseini,Ali Khademhosseini,Ali Khademhosseini,Nasim Annabi,Nasim Annabi,Nasim Annabi +21 more
TL;DR: The developed visible light crosslinked hydrogel could be used for the repair of various soft tissues such as the myocardium and for the treatment of cardiovascular diseases with enhanced therapeutic functionality.
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Young developmental age cardiac extracellular matrix promotes the expansion of neonatal cardiomyocytes in vitro.
TL;DR: The effects of fetal, neonatal and adult cardiac ECM on the expansion of neonatal rat ventricular cells in vitro are studied and it is suggested that proliferation may be a major mechanism of cardiomyocyte expansion on young ECM.
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Cell-induced alignment augments twitch force in fibrin gel-based engineered myocardium via gap junction modification.
TL;DR: Regardless of the specific mechanism, the results presented in this study underscore the importance of recapitulating the anisotropy of the native tissue in engineered myocardium.