Young developmental age cardiac extracellular matrix promotes the expansion of neonatal cardiomyocytes in vitro.
TLDR
The effects of fetal, neonatal and adult cardiac ECM on the expansion of neonatal rat ventricular cells in vitro are studied and it is suggested that proliferation may be a major mechanism of cardiomyocyte expansion on young ECM.About:
This article is published in Acta Biomaterialia.The article was published on 2014-01-01 and is currently open access. It has received 159 citations till now. The article focuses on the topics: Extracellular matrix & Population.read more
Citations
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Electrical and mechanical stimulation of cardiac cells and tissue constructs.
TL;DR: The biological underpinnings of both mechanical and electrical signaling, as identified via studies related to cardiac development and those related to an evaluation of cardiac disease progression are sought, as well as the development of bioreactors that combine electrical and mechanical stimulation in order to mimic the complex signaling environment present in vivo.
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Extracellular matrix hydrogel therapies: In vivo applications and development.
TL;DR: This review will focus on in vivo applications of ECM hydrogels and functional outcomes in disease models, as well as discuss considerations for clinical translation.
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Naturally Engineered Maturation of Cardiomyocytes
TL;DR: Although the end goal is to achieve adult phenotypic maturity, more emphasis must be placed on elucidating how the in vivo fetal microenvironment drives cardiomyocyte maturation, to make prominent progress in pluripotent stem cell-derived maturity toward a more clinically relevant model for cardiac regeneration.
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Dynamically Tunable Cell Culture Platforms for Tissue Engineering and Mechanobiology.
TL;DR: In vitro efforts to mimic the dynamic microenvironment comprising native tissue ECM from the viewpoint of material design and how these dynamic polymer-based biomaterials are being used in fundamental cell mechanobiology studies, as well as towards efforts in tissue engineering and regenerative medicine are reviewed.
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Decellularized myocardial matrix hydrogels: In basic research and preclinical studies.
TL;DR: This review will focus on the basic science and preclinical studies that have accelerated the development of decellularized myocardial matrix hydrogels into an emerging novel therapy for treating the heart after aMyocardial infarction.
References
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Evidence for cardiomyocyte renewal in humans
Olaf Bergmann,Ratan D. Bhardwaj,Samuel Bernard,Sofia Zdunek,Fanie Barnabé-Heider,Stuart Walsh,Joel Zupicich,Kanar Alkass,Bruce A. Buchholz,Henrik Druid,Stefan Jovinge,Jonas Frisén +11 more
TL;DR: The capacity to generate cardiomyocytes in the adult human heart suggests that it may be rational to work toward the development of therapeutic strategies aimed at stimulating this process in cardiac pathologies.
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Perfusion-decellularized matrix: using nature's platform to engineer a bioartificial heart
Harald C. Ott,Thomas S Matthiesen,Saik Kia Goh,Lauren D. Black,Stefan M. Kren,Theoden I. Netoff,Doris A. Taylor +6 more
TL;DR: Eight constructs decellularized hearts by coronary perfusion with detergents, preserved the underlying extracellular matrix, and produced an acellular, perfusable vascular architecture, competent a cellular valves and intact chamber geometry that could generate pump function in a modified working heart preparation.
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Transient regenerative potential of the neonatal mouse heart
Enzo R. Porrello,Ahmed I. Mahmoud,Emma Simpson,Joseph A. Hill,James A. Richardson,Eric N. Olson,Hesham A. Sadek +6 more
TL;DR: It is found that the hearts of 1-day-old neonatal mice can regenerate after partial surgical resection, but this capacity is lost by 7 days of age, which means that for a brief period after birth, the mammalian heart appears to have the capacity to regenerate.
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Decellularization of tissues and organs
TL;DR: The most commonly used decellularization methods are described, and consideration give to the effects of these methods upon the biologic scaffold material.
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The extracellular matrix as a biologic scaffold material.
TL;DR: The factors that appear important for the constructive remodeling of ECM biologic scaffolds are its ability to be rapidly and completely degraded with the generation of downstream bioactive molecules and the ability to engineer its mechanical properties at the time of implantation through an understanding of its collagen fiber microstructure.