Lauren Miller

TL;DR: Targeting the interaction between the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein and the human angiotensin-converting enzyme 2 (ACE2) receptor is a promising therapeutic strategy and small, stable proteins that bind tightly to the spike and block it from binding to ACE2 are designed.

TL;DR: In this article , the authors describe a general solution to this problem that starts with a broad exploration of the vast space of possible binding modes to a selected region of a protein surface and then intensifies the search in the vicinity of the most promising binding modes.

TL;DR: It is demonstrated that genes involved in creatine metabolism, the creatine kinases (CKs), are coordinately regulated by hypoxia-inducible transcription factors (HIFs) and that such regulation is critical to barrier function.

TL;DR: Cryo-electron microscopy structures of the designs and their binding interactions with the RBD are nearly identical to the computational models, and that all three RBDs in a single Spike protein can be engaged simultaneously.

TL;DR: In this paper, a general solution to the problem of protein-protein interaction design is described, which starts with a broad exploration of the very large space of possible binding modes and interactions, and then intensifies the search in the most promising regions.