L
Laurent Ferrier
Researcher at Institut national de la recherche agronomique
Publications - 44
Citations - 3588
Laurent Ferrier is an academic researcher from Institut national de la recherche agronomique. The author has contributed to research in topics: Inflammation & Irritable bowel syndrome. The author has an hindex of 26, co-authored 44 publications receiving 3211 citations. Previous affiliations of Laurent Ferrier include University of Toulouse.
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Journal ArticleDOI
Prevention of gut leakiness by a probiotic treatment leads to attenuated HPA response to an acute psychological stress in rats.
Afifa Ait-Belgnaoui,Henri Durand,Christel Cartier,Gilles Chaumaz,Helene Eutamene,Laurent Ferrier,Eric Houdeau,Jean Fioramonti,Lionel Bueno,Vassilia Theodorou +9 more
TL;DR: The attenuation of the HPA axis response to stress by L. farciminis depends upon the prevention of intestinal barrier impairment and decrease of circulating LPS levels.
Journal ArticleDOI
The food contaminant deoxynivalenol, decreases intestinal barrier permeability and reduces claudin expression.
Philippe Pinton,Jean-Philippe Nougayrède,Juan-Carlos Del Rio,Carolina Moreno,Daniela Eliza Marin,Laurent Ferrier,Ana Paula Frederico Rodrigues Loureiro Bracarense,Martine Kolf-Clauw,Isabelle P. Oswald +8 more
TL;DR: Don alters claudin expression and decreases the barrier function of the intestinal epithelium, and consumption of DON-contaminated food/feed may induce intestinal damage and has consequences for human and animal health.
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Increased faecal serine protease activity in diarrhoeic IBS patients: a colonic lumenal factor impairing colonic permeability and sensitivity
Krisztina Gecse,Richárd Róka,Laurent Ferrier,Mathilde Leveque,Helene Eutamene,Christel Cartier,Afifa Ait-Belgnaoui,András Rosztóczy,Ferenc Izbéki,Jean Fioramonti,Tibor Wittmann,Lionel Bueno +11 more
TL;DR: Elevated colonic lumenal serine protease activity of IBS-D patients evokes a PAR-2-mediated colonic epithelial barrier dysfunction and subsequent allodynia in mice, suggesting a novel organic background in the pathogenesis of Ibs.
Journal ArticleDOI
Neonatal maternal deprivation triggers long term alterations in colonic epithelial barrier and mucosal immunity in rats
TL;DR: A role for early psychological factors in the regulation of colonic mucosal barrier in later life is suggested, as judged by enhanced MPO colonic levels, total gut permeability, and macroscopic lesions.
Journal ArticleDOI
Impairment of the Intestinal Barrier by Ethanol Involves Enteric Microflora and Mast Cell Activation in Rodents
Laurent Ferrier,Florian Bérard,Laurent Debrauwer,Chantal Chabo,Philippe Langella,Lionel Bueno,Jean Fioramonti +6 more
TL;DR: It is demonstrated that an acute and moderate ethanol intake alters the epithelial barrier through ethanol oxidation into acetaldehyde by the colonic microflora and downstream mast cell activation, which could explain the subsequent endotoxemia frequently observed in patients with alcoholic liver disease.