M
Mathilde Leveque
Researcher at University of Toulouse
Publications - 35
Citations - 2884
Mathilde Leveque is an academic researcher from University of Toulouse. The author has contributed to research in topics: Colitis & Medicine. The author has an hindex of 19, co-authored 31 publications receiving 2521 citations. Previous affiliations of Mathilde Leveque include Paris Descartes University & French Institute of Health and Medical Research.
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Journal ArticleDOI
Blood-brain barrier-specific properties of a human adult brain endothelial cell line
Babette B. Weksler,E. A. Subileau,N. Perrière,Pierre Charneau,Karen Holloway,Mathilde Leveque,H. Tricoire-Leignel,A. Nicotra,Sandrine Bourdoulous,Patric Turowski,David Male,Françoise Roux,John Greenwood,Ignacio A. Romero,P.O. Couraud +14 more
TL;DR: In this article, normal human brain endothelial cells were transduced by lentiviral vectors incorporating human telomerase or SV40 T antigen, and one was selected for expression of normal endothelial markers, including CD31, VE cadherin, and von Willebrand factor.
Journal ArticleDOI
Increased faecal serine protease activity in diarrhoeic IBS patients: a colonic lumenal factor impairing colonic permeability and sensitivity
Krisztina Gecse,Richárd Róka,Laurent Ferrier,Mathilde Leveque,Helene Eutamene,Christel Cartier,Afifa Ait-Belgnaoui,András Rosztóczy,Ferenc Izbéki,Jean Fioramonti,Tibor Wittmann,Lionel Bueno +11 more
TL;DR: Elevated colonic lumenal serine protease activity of IBS-D patients evokes a PAR-2-mediated colonic epithelial barrier dysfunction and subsequent allodynia in mice, suggesting a novel organic background in the pathogenesis of Ibs.
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Impact of oral bisphenol A at reference doses on intestinal barrier function and sex differences after perinatal exposure in rats
Viorica Braniste,Aurore Jouault,Eric Gaultier,Arnaud Polizzi,Claire Buisson-Brenac,Mathilde Leveque,Pascal G.P. Martin,Vassilia Theodorou,Jean Fioramonti,Eric Houdeau +9 more
TL;DR: It is demonstrated that the xenoestrogen BPA at reference doses influences intestinal barrier function and gut nociception, and perinatal exposure promotes the development of severe inflammation in adult female offspring only.
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Pathways involved in gut mucosal barrier dysfunction induced in adult rats by maternal deprivation: corticotrophin‐releasing factor and nerve growth factor interplay
Frédérick Barreau,Christel Cartier,Mathilde Leveque,Laurent Ferrier,Raphael Moriez,Valérie Laroute,András Rosztóczy,Jean Fioramonti,Lionel Bueno +8 more
TL;DR: CRF acts through CRF‐R1 receptors to stimulate NGF release from mast cells, which participates in the elevated GPP observed in NMD adult rats, which suggests that early traumatic experience induced neuro‐endocrine dysfunction, involved in alterations of gut mucosal barrier.
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Oestradiol decreases colonic permeability through oestrogen receptor β-mediated up-regulation of occludin and junctional adhesion molecule-A in epithelial cells
Viorica Braniste,Mathilde Leveque,Claire Buisson-Brenac,Lionel Bueno,Jean Fioramonti,Eric Houdeau +5 more
TL;DR: Data show that oestrogen reinforces intestinal epithelial barrier through ERβ‐mediated up‐regulation of the transmembrane proteins occludin and JAM‐A determining paracellular spaces.