L
Lauriane Lecoq
Researcher at University of Lyon
Publications - 37
Citations - 647
Lauriane Lecoq is an academic researcher from University of Lyon. The author has contributed to research in topics: Capsid & Medicine. The author has an hindex of 12, co-authored 28 publications receiving 389 citations. Previous affiliations of Lauriane Lecoq include Centre national de la recherche scientifique & Claude Bernard University Lyon 1.
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Journal ArticleDOI
Kinetic features of L,D-transpeptidase inactivation critical for β-lactam antibacterial activity.
Sébastien Triboulet,Sébastien Triboulet,Sébastien Triboulet,Vincent Dubée,Vincent Dubée,Vincent Dubée,Lauriane Lecoq,Lauriane Lecoq,Catherine M. Bougault,Catherine M. Bougault,Jean-Luc Mainardi,Louis B. Rice,Mélanie Etheve-Quelquejeu,Mélanie Etheve-Quelquejeu,Laurent Gutmann,Arul Marie,Lionel Dubost,Jean-Emmanuel Hugonnet,Jean-Emmanuel Hugonnet,Jean-Emmanuel Hugonnet,Jean-Pierre Simorre,Jean-Pierre Simorre,Michel Arthur,Michel Arthur,Michel Arthur +24 more
TL;DR: It is shown that imipenem, ceftriaxone, and ampicillin acylate Ldtfm by formation of a thioester bond between the active-site cysteine and the β-lactam-ring carbonyl, which is critical for rapid L,D-transpeptidase inactivation and antibacterial activity.
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Hepatitis B virus core protein phosphorylation: Identification of the SRPK1 target sites and impact of their occupancy on RNA binding and capsid structure
TL;DR: A bacterial coexpression system enabling access to definably phosphorylated HBc and suggesting a mechanism whereby high-level HBc phosphorylation principally suppresses RNA binding whereas one or few strategic dephosphorylation events enable selective packaging of the pgRNA/polymerase complex is developed.
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Protein NMR Spectroscopy at 150 kHz Magic-Angle Spinning Continues To Improve Resolution and Mass Sensitivity
Maarten Schledorn,Alexander A. Malär,Anahit Torosyan,Susanne Penzel,Daniel Klose,Andres Oss,Mai-Liis Org,Shishan Wang,Lauriane Lecoq,Riccardo Cadalbert,Ago Samoson,Anja Böckmann,Beat H. Meier +12 more
TL;DR: It is concluded that even faster MAS is highly attractive and increases mass sensitivity at a moderate price in overall sensitivity.
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Solid-state NMR and EPR Spectroscopy of Mn2+-Substituted ATP-Fueled Protein Engines
Thomas Wiegand,Denis Lacabanne,Katharina Keller,Riccardo Cadalbert,Lauriane Lecoq,Maxim Yulikov,Laurent Terradot,Gunnar Jeschke,Beat H. Meier,Anja Böckmann +9 more
TL;DR: It is shown that, while EPR spectra report on metal binding and provide information on the geometry of the metal centers in the proteins, paramagnetic relaxation enhancements identified in the NMR spectra can be used to localize residues at the binding site.
Journal ArticleDOI
Structure of Enterococcus faeciuml,d-transpeptidase acylated by ertapenem provides insight into the inactivation mechanism.
Lauriane Lecoq,Vincent Dubée,Vincent Dubée,Vincent Dubée,Sébastien Triboulet,Sébastien Triboulet,Sébastien Triboulet,Catherine M. Bougault,Jean-Emmanuel Hugonnet,Jean-Emmanuel Hugonnet,Jean-Emmanuel Hugonnet,Michel Arthur,Michel Arthur,Michel Arthur,Jean-Pierre Simorre +14 more
TL;DR: The first structure of a carbapenem-acylated l,d-transpeptidase is presented, E. faecium Ldtfm acylated by ertapenems, which revealed key contacts between the carbapanem core and residues of the catalytic cavity of the enzyme.