L
Laurie Ailles
Researcher at University of Toronto
Publications - 111
Citations - 16147
Laurie Ailles is an academic researcher from University of Toronto. The author has contributed to research in topics: Stem cell & Cancer stem cell. The author has an hindex of 36, co-authored 101 publications receiving 14694 citations. Previous affiliations of Laurie Ailles include University of Turin & University Health Network.
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Journal ArticleDOI
A role for Wnt signalling in self-renewal of haematopoietic stem cells
Tannishtha Reya,Andrew W. Duncan,Laurie Ailles,Jos Domen,David C. Scherer,Karl Willert,Lindsay Hintz,Roel Nusse,Irving L. Weissman +8 more
TL;DR: It is concluded that the Wnt signalling pathway is critical for normal HSC homeostasis in vitro and in vivo, and insight is provided into a potential molecular hierarchy of regulation of HSC development.
Journal ArticleDOI
Association of reactive oxygen species levels and radioresistance in cancer stem cells
Maximilian Diehn,Robert W. Cho,Neethan A. Lobo,Tomer Kalisky,Mary Jo Dorie,Angela N. Kulp,Dalong Qian,Jessica Lam,Laurie Ailles,Manzhi Wong,Benzion Joshua,Michael J. Kaplan,Irene Wapnir,Frederick M. Dirbas,George Somlo,Carlos A. Garberoglio,Benjamin Paz,Jeannie Shen,Sean K. Lau,Stephen R. Quake,J. Martin Brown,Irving L. Weissman,Michael F. Clarke +22 more
TL;DR: It is shown that normal mammary epithelial stem cells contain lower concentrations of ROS than their more mature progeny cells, and subsets of CSCs in some tumours contain lower ROS levels and enhanced ROS defences compared to their non-tumorigenic progeny, which may contribute to tumour radioresistance.
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Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma
Mark E. Prince,Ranjiv Sivanandan,Andrew J. Kaczorowski,Gregory T. Wolf,Michael J. Kaplan,Piero Dalerba,Irving L. Weissman,Michael F. Clarke,Laurie Ailles +8 more
TL;DR: Data demonstrate that cells within the CD44+ population of human HNSCC possess the unique properties of cancer stem cells in functional assays for cancer stem cell self-renewal and differentiation and form unique histological microdomains that may aid in cancer diagnosis.
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Granulocyte-Macrophage Progenitors as Candidate Leukemic Stem Cells in Blast-Crisis CML
Catriona Jamieson,Laurie Ailles,Scott J. Dylla,Manja Muijtjens,Carol D. Jones,James L. Zehnder,Jason Gotlib,Kevin Li,Markus G. Manz,Armand Keating,Charles L. Sawyers,Irving L. Weissman +11 more
TL;DR: Activation of beta-catenin in CML granulocyte-macrophage progenitors appears to enhance the self-renewal activity and leukemic potential of these cells.
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Gene transfer by lentiviral vectors is limited by nuclear translocation and rescued by HIV-1 pol sequences.
TL;DR: The results indicate that nuclear translocation of the genome is a rate-limiting step in lentiviral infection of both dividing and non-dividing cells, and that it depends on protein and nucleic acid sequence determinants.