L
Lawrence B. Cohen
Researcher at Yale University
Publications - 138
Citations - 10228
Lawrence B. Cohen is an academic researcher from Yale University. The author has contributed to research in topics: Olfactory bulb & Population. The author has an hindex of 53, co-authored 132 publications receiving 9831 citations. Previous affiliations of Lawrence B. Cohen include Amherst College & Columbia University.
Papers
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Book ChapterDOI
Optical measurement of membrane potential.
TL;DR: The use of redistribution signals, which are slower, and thus more likely to represent to secondary effects of changes in membrane potential, and require permeant dyes with access to the internal millieu, may be more hazardous than the use of either fast or intrinsic signals.
Journal ArticleDOI
Single Action Potentials and Subthreshold Electrical Events Imaged in Neurons with a Fluorescent Protein Voltage Probe
Lei Jin,Zhou Han,Jelena Platisa,Julian R. A. Wooltorton,Lawrence B. Cohen,Lawrence B. Cohen,Vincent A. Pieribone +6 more
TL;DR: The development of a fluorescent protein voltage sensor, named ArcLight, and derivative probes that exhibit large changes in fluorescence intensity in response to voltage changes are reported, which allows the reliable detection of single action potentials and excitatory potentials in individual neurons and dendrites.
Journal ArticleDOI
Representation of odorants by receptor neuron input to the mouse olfactory bulb.
TL;DR: To visualize odorant representations by receptor neuron input to the mouse olfactory bulb, receptor neurons were loaded with calcium-sensitive dye and imaged odorant-evoked responses from their axon terminals and five glomeruli were identifiable across animals based on their location and odorant responsiveness.
Journal ArticleDOI
Light Scattering and Birefringence Changes during Nerve Activity
TL;DR: Two optical techniques—light scattering and birefringence—have been used to detect rapid structural changes accompanying the action potentials in two types of non-myelinated nerve fibre.
Journal ArticleDOI
Changes in axon fluorescence during activity: Molecular probes of membrane potential
Lawrence B. Cohen,Lawrence B. Cohen,Lawrence B. Cohen,Brian M. Salzberg,Brian M. Salzberg,Brian M. Salzberg,H. V. Davila,H. V. Davila,H. V. Davila,William N. Ross,William N. Ross,William N. Ross,D. Landowne,D. Landowne,D. Landowne,A. S. Waggoner,A. S. Waggoner,A. S. Waggoner,C. H. Wang,C. H. Wang,C. H. Wang +20 more
TL;DR: The fluorescence of dyes added to squid giant axons was studied during action potentials and voltage-clamp steps to find large changes in fluorescence that would allow optical monitoring of membrane potential in neurons and other cells.