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Lawrence M. Nelson

Researcher at National Institutes of Health

Publications -  127
Citations -  7616

Lawrence M. Nelson is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Premature ovarian failure & Antigen. The author has an hindex of 49, co-authored 125 publications receiving 6956 citations.

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Mater, a maternal effect gene required for early embryonic development in mice.

TL;DR: It is shown here that Mater, a mouse oocyte protein dependent on the maternal genome, is essential for embryonic development beyond the two-cell stage.
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The FMR1 premutation and reproduction.

TL;DR: There are major gaps in knowledge regarding the natural history of the altered ovarian function in women who carry the FMR1 premutation, making counseling about reproductive plans a challenge and specialists in reproductive medicine can provide a supportive environment in which to explain the implications.
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A potential novel mechanism for precocious puberty in juvenile hypothyroidism.

TL;DR: Rec-hTSH acted as a competitive inhibitor of hF SH at the hFSH-R, indicating that hTSH and hFsh are acting through the same receptor, namely the hHTSH, and provides a potential novel mechanism for the precocious puberty of juvenile hypothyroidism.
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An update: spontaneous premature ovarian failure is not an early menopause.

TL;DR: There is a need to first address physical and mental health issues before addressing plans for family building, and clinicians need to be sensitive to the emotional aspects of this disorder when delivering the diagnosis and during subsequent management.