L
Lawrence P. Brett
Researcher at Western General Hospital
Publications - 6
Citations - 1719
Lawrence P. Brett is an academic researcher from Western General Hospital. The author has contributed to research in topics: Corticosterone & Mineralocorticoid receptor. The author has an hindex of 6, co-authored 6 publications receiving 1695 citations.
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Journal ArticleDOI
LOCALISATION OF 11β-HYDROXYSTEROID DEHYDROGENASE—TISSUE SPECIFIC PROTECTOR OF THE MINERALOCORTICOID RECEPTOR
C. R. W. Edwards,D. Burt,M.A. Mcintyre,E.R. de Kloet,Paul M. Stewart,Lawrence P. Brett,W. Sutanto,Carl Monder +7 more
TL;DR: Findings seem to explain why sodium retention, hypokalaemia, and hypertension develop in subjects with congenital deficiency of 11 beta-OHSD and those in whom the enzyme has been inhibited by liquorice.
Journal ArticleDOI
Cloning and production of antisera to human placental 11 beta-hydroxysteroid dehydrogenase type 2.
Roger W. Brown,Karen E. Chapman,Yuri Kotelevtsev,Joyce L.W. Yau,Robbie S. Lindsay,Lawrence P. Brett,Caroline Mckenzie Leckie,Parvez Murad,Val Lyons,John J. Mullins,Christopher R. W. Edwards,Jonathan R. Seckl +11 more
TL;DR: 11 beta-HSD2 transcripts are expressed in fetal kidney at 21-26 weeks, suggesting that an 11 beta- HSD2 distribution resembling that in the adult is established by this stage in human development.
Journal ArticleDOI
Potentiation of hydrocortisone activity in skin by glycyrrhetinic acid.
TL;DR: The enzyme 11 beta-hydroxysteroid dehydrogenase (11 beta-OHSD) was demonstrated by immunohistochemistry in skin biopsy samples from healthy volunteers and from patients with psoriasis and eczema as mentioned in this paper.
Journal ArticleDOI
1lβ-Hydroxysteroid Dehydrogenase in Vascular Smooth Muscle and Heart: Implications for Cardiovascular Responses to Glucocorticoids
Brian R. Walker,Joyce L.W. Yau,Lawrence P. Brett,Jonathan R. Seckl,Carl Monder,Brent C. Williams,Christopher R. W. Edwards +6 more
TL;DR: 11 beta-OHSD is appropriately sited to modulate access of corticosterone to vascular receptors and could influence vascular resistance, cardiac output and thereby blood pressure.
Journal Article
Distribution of glucocorticoid and mineralocorticoid receptors and 11beta-hydroxysteroid dehydrogenases in human and rat ocular tissues.
John Stokes,John Stokes,June Noble,Lawrence P. Brett,Calbert I. Phillips,Jonathan R. Seckl,Colm O'Brien,Ruth Andrew +7 more
TL;DR: The purpose of this study was to determine the distribution of glucocorticoid target receptors and the isozymes of 11beta-hydroxysteroid dehydrogenase (11 beta-HSD) that regulate the activity of glucOCorticoids at a prereceptor level in human and rat ocular tissues.