L
Le Zhang
Researcher at Third Military Medical University
Publications - 12
Citations - 514
Le Zhang is an academic researcher from Third Military Medical University. The author has contributed to research in topics: Cell growth & Viral replication. The author has an hindex of 8, co-authored 12 publications receiving 425 citations.
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Journal ArticleDOI
Protective effect of berberine on beta cells in streptozotocin- and high-carbohydrate/high-fat diet-induced diabetic rats
Jiyin Zhou,Shiwen Zhou,Jianlin Tang,Kebin Zhang,Lixia Guang,Yongping Huang,Ying Xu,Yi Ying,Le Zhang,Dandan Li +9 more
TL;DR: It is suggested that berberine has protective effect for diabetes through increasing insulin expression, beta cell regeneration, antioxidant enzyme activity and decreasing lipid peroxidation.
Journal ArticleDOI
Chronic effects of berberine on blood, liver glucolipid metabolism and liver PPARs expression in diabetic hyperlipidemic rats.
Ji Yin Zhou,Shi Wen Zhou,Ke Bin Zhang,Jian Lin Tang,Li Xia Guang,Yi Ying,Ying Xu,Le Zhang,Dandan Li +8 more
TL;DR: Berberine improved glucolipid metabolism both in blood and liver in diabetic rats possibly through modulating the metabolic related PPARalpha/delta/gamma protein expression in liver.
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Down-regulation of miR-34a alleviates mesangial proliferation in vitro and glomerular hypertrophy in early diabetic nephropathy mice by targeting GAS1.
Le Zhang,Siyi He,Shaodong Guo,Wei Xie,Rong Xin,Hua Yu,Fan Yang,Jing Qiu,Di Zhang,Shiwen Zhou,Kebin Zhang +10 more
TL;DR: Down-regulation of miR-34a inhibits mice mesangial cells (MMCs) proliferation in vitro and alleviates glomerular hypertrophy in vivo and GAS1 was proved to be the target of miGAS1 through luciferase report.
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Metformin Induces Growth Inhibition and Cell Cycle Arrest by Upregulating MicroRNA34a in Renal Cancer Cells.
TL;DR: It was demonstrated that inhibition of miRNA34a could partially attenuate the suppressive effect of metformin on renal cancer cell proliferation and cell growth inhibition and cell cycle arrest partially by upregulating mi RNA34a in renal cancer cells.
Journal ArticleDOI
Hyperoside ameliorates glomerulosclerosis in diabetic nephropathy by downregulating miR-21
Le Zhang,Siyi He,Fan Yang,Hua Yu,Wei Xie,Qian Dai,Di Zhang,Xiaoqin Liu,Shiwen Zhou,Kebin Zhang +9 more
TL;DR: It is suggested that Hyp can ameliorate glomerulosclerosis in diabetic nephropathy by downregulating miR-21 to increase expression of its target, MMP-9.