Journal ArticleDOI
Protective effect of berberine on beta cells in streptozotocin- and high-carbohydrate/high-fat diet-induced diabetic rats
Jiyin Zhou,Shiwen Zhou,Jianlin Tang,Kebin Zhang,Lixia Guang,Yongping Huang,Ying Xu,Yi Ying,Le Zhang,Dandan Li +9 more
TLDR
It is suggested that berberine has protective effect for diabetes through increasing insulin expression, beta cell regeneration, antioxidant enzyme activity and decreasing lipid peroxidation.About:
This article is published in European Journal of Pharmacology.The article was published on 2009-03-15. It has received 181 citations till now. The article focuses on the topics: Streptozotocin & Beta cell.read more
Citations
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Journal ArticleDOI
Endoplasmic Reticulum Stress: Its Role in Disease and Novel Prospects for Therapy
TL;DR: The cell reacts to ER stress by initiating a defensive process, called the unfolded protein response (UPR), which is comprised of cellular mechanisms aimed at adaptation and safeguarding cellular survival or, in cases of excessively severe stress, at initiation of apoptosis and elimination of the faulty cell.
Journal ArticleDOI
Berberine: a potential phytochemical with multispectrum therapeutic activities.
TL;DR: A relatively large number of studies discussed here have revealed the possible areas where this phytochemical constituent can exhibit its therapeutic activities in the treatment of chronic ailments or diseases including diabetes, cancer, depression, hypertension and hypercholesterolemia.
Journal ArticleDOI
Diabetes is an inflammatory disease: evidence from traditional Chinese medicines.
TL;DR: Traditional Chinese medicines (TCM) play an important role in lowering blood glucose and controlling inflammation and diverse TCM may share a common antidiabetic property: anti‐inflammatory action.
Journal ArticleDOI
Antioxidant and Anti-Inflammatory Activities of Berberine in the Treatment of Diabetes Mellitus
TL;DR: Mechanisms of the antioxidant and anti-inflammatory activities of BBR were complex, which involved multiple cellular kinases and signaling pathways, such as AMP-activated protein kinase (AMPK), mitogen-activatedprotein kinases (MAPKs), nuclear factor erythroid-2-related factor-2 (Nrf2) pathway, and nuclear factor-κB (NF-κBs) pathway.
Journal ArticleDOI
Therapeutic potential of nucleic acid-binding isoquinoline alkaloids: binding aspects and implications for drug design.
TL;DR: Up‐to‐date details of the interaction of berberine, palmatine, and jatrorrhizine of the protoberberine group, sanguinarine from the benzophananthridines group, and several of their synthetic derivatives, such as coralyne, berberrubine,Palmatrubin, andJatrorubin with nucleic acids have been reviewed.
References
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Journal ArticleDOI
Effect of Rosiglitazone on the Risk of Myocardial Infarction and Death from Cardiovascular Causes
Steven E. Nissen,Kathy Wolski +1 more
TL;DR: Patients and providers should consider the potential for serious adverse cardiovascular effects of treatment with rosiglitazone for type 2 diabetes mellitus as well as the availability of outcome data for myocardial infarction and death from cardiovascular causes.
Book ChapterDOI
Malondialdehyde determination as index of lipid peroxidation
H H Draper,M Hadley +1 more
TL;DR: This chapter describes the malondialdehyde (MDA) as index of lipid peroxidation, a determination that appears to offer a facile means of assessing lipidperoxidation in biological materials.
Journal Article
A modified spectrophotometric assay of superoxide dismutase.
TL;DR: A simple and rapid method for the assay of superoxide dismutase in biological samples is described, which takes advantage of the inhibition of NADH-dependent-nitroblue tetrazolium reduction by the dismut enzyme.
Journal ArticleDOI
Role of oxidative stress in diabetic complications: a new perspective on an old paradigm.
John W. Baynes,S R Thorpe +1 more
TL;DR: In this article, the authors investigated whether increased oxidative stress has a primary role in the pathogenesis of diabetic complications or whether it is a secondary indicator of end-stage tissue damage in diabetes.
Thorpe sr role of oxidative stress in diabetic complications: a new perspective on an old paradigm
TL;DR: It is proposed that the increased chemical modification of proteins by carbohydrates and lipids in diabetes is the result of overload on metabolic pathways involved in detoxification of reactivecarbonyl species, leading to a general increase in steady-state levels of reactive carbonyl compounds formed by both oxidative and nonoxidative reactions.
Related Papers (5)
Efficacy of berberine in patients with type 2 diabetes mellitus
Jun Yin,Huili Xing,Jianping Ye +2 more