Lee Sam

TL;DR: The mutational landscape of a heavily treated metastatic cancer is described, novel mechanisms of AR signalling deregulated in prostate cancer are identified, and candidates for future study are prioritize.

TL;DR: A robust pipeline is established for the discovery of novel gene chimaeras using high-throughput sequencing of cancer cells to discover novel gene fusions resulting in chimaeric transcripts in cancer cell lines and tumours.

TL;DR: The mutations present in advanced cancers can be identified by integrative high-throughput sequencing to enable biomarker-driven clinical trials and, ultimately, treatment and the authors tested this approach by extensively characterizing cancers in several patients and then convening a Sequencing Tumor Board of experts to determine the appropriate treatment.

TL;DR: This comprehensive methylome map will further the understanding of epigenetic regulation in prostate cancer progression and observed differences in repeat element methylation, particularly LINE-1, between ERG gene fusion-positive and -negative cancers.