B
Bo Han
Researcher at Shandong University
Publications - 102
Citations - 9142
Bo Han is an academic researcher from Shandong University. The author has contributed to research in topics: Prostate cancer & Cancer. The author has an hindex of 30, co-authored 81 publications receiving 8282 citations. Previous affiliations of Bo Han include University of Michigan.
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Journal ArticleDOI
Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression
Arun Sreekumar,Laila M. Poisson,Thekkelnaycke M. Rajendiran,Amjad Khan,Qi Cao,Jindan Yu,Bharathi Laxman,Rohit Mehra,Robert J. Lonigro,Yong Li,Mukesh K. Nyati,Aarif Ahsan,Shanker Kalyana-Sundaram,Bo Han,Xuhong Cao,Jaeman Byun,Gilbert S. Omenn,Debashis Ghosh,Subramaniam Pennathur,Danny C. Alexander,Alvin Berger,Jeffrey R. Shuster,John T. Wei,Sooryanarayana Varambally,Christopher A. Beecher,Arul M. Chinnaiyan +25 more
TL;DR: Sarcosine, an N-methyl derivative of the amino acid glycine, was identified as a differential metabolite that was highly increased during prostate cancer progression to metastasis and can be detected non-invasively in urine.
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Genomic Loss of microRNA-101 Leads to Overexpression of Histone Methyltransferase EZH2 in Cancer
Sooryanarayana Varambally,Qi Cao,Ram Shankar Mani,Sunita Shankar,Xiaosong Wang,Bushra Ateeq,Bharathi Laxman,Xuhong Cao,Xiaojun Jing,Kalpana Ramnarayanan,J. Chad Brenner,Jindan Yu,Jung H. Kim,Bo Han,Patrick Tan,Chandan Kumar-Sinha,Robert J. Lonigro,Nallasivam Palanisamy,Nallasivam Palanisamy,Christopher G. Maher,Arul M. Chinnaiyan +20 more
TL;DR: The expression and function of EZH2 in cancer cell lines are inhibited by microRNA-101 and it is proposed that the genomic loss of miR-101 in cancer leads to overexpression of EzH2 and concomitant dysregulation of epigenetic pathways, resulting in cancer progression.
Journal ArticleDOI
Transcriptome Sequencing to Detect Gene Fusions in Cancer
Christopher G. Maher,Chandan Kumar-Sinha,Xuhong Cao,Shanker Kalyana-Sundaram,Bo Han,Xiaojun Jing,Lee Sam,Terrence R. Barrette,Nallasivam Palanisamy,Arul M. Chinnaiyan +9 more
TL;DR: A robust pipeline is established for the discovery of novel gene chimaeras using high-throughput sequencing of cancer cells to discover novel gene fusions resulting in chimaeric transcripts in cancer cell lines and tumours.
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Androgen receptor regulates a distinct transcription program in androgen-independent prostate cancer
Qianben Wang,Wei Li,Yong Zhang,Xin Yuan,Kexin Xu,Jindan Yu,Zhong Chen,Rameen Beroukhim,Rameen Beroukhim,Hongyun Wang,Mathieu Lupien,Tao Wu,Meredith M. Regan,Clifford A. Meyer,Jason S. Carroll,Arjun K. Manrai,Olli A. Jänne,Steven P. Balk,Rohit Mehra,Bo Han,Arul M. Chinnaiyan,Mark A. Rubin,Lawrence D. True,Michelangelo Fiorentino,Christopher Fiore,Massimo Loda,Philip W. Kantoff,X. Shirley Liu,Myles Brown +28 more
TL;DR: The role of AR in androgen-independent cancer cells is not to direct the androgen -dependent gene expression program without androgen, but rather to execute a distinct program resulting in androgens-independent growth.
Journal ArticleDOI
Distinct classes of chromosomal rearrangements create oncogenic ETS gene fusions in prostate cancer
Scott A. Tomlins,Bharathi Laxman,Saravana M. Dhanasekaran,Beth E. Helgeson,Xuhong Cao,David S. Morris,Anjana Menon,Xiaojun Jing,Qi Cao,Bo Han,Jindan Yu,Lei Wang,James E. Montie,Mark A. Rubin,Kenneth J. Pienta,Diane Roulston,Rajal B. Shah,Sooryanarayana Varambally,Rohit Mehra,Arul M. Chinnaiyan +19 more
TL;DR: Identification of distinct classes of ETS gene rearrangements demonstrates that dormant oncogenes can be activated in prostate cancer by juxtaposition to tissue-specific or ubiquitously active genomic loci.