L
Leendert W. Hamoen
Researcher at University of Amsterdam
Publications - 102
Citations - 7568
Leendert W. Hamoen is an academic researcher from University of Amsterdam. The author has contributed to research in topics: Bacillus subtilis & Gene. The author has an hindex of 45, co-authored 94 publications receiving 6602 citations. Previous affiliations of Leendert W. Hamoen include Newcastle University & University of Groningen.
Papers
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Journal ArticleDOI
Membrane potential is important for bacterial cell division
Henrik Strahl,Leendert W. Hamoen +1 more
TL;DR: It is reported that the proton motive force, or more specifically the (trans)membrane potential, is directly involved in protein localization and has implications for how these morphogenetic proteins work and provides an explanation for the effects observed with certain antimicrobial compounds.
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Bet-hedging and epigenetic inheritance in bacterial cell development
Jan-Willem Veening,Eric J. Stewart,Eric J. Stewart,Thomas W. Berngruber,François Taddei,François Taddei,Oscar P. Kuipers,Leendert W. Hamoen +7 more
TL;DR: It is demonstrated that B. subtilis is subject to aging, and the physiological state of the cell's ancestor (more than two generations removed) does affect the outcome of cellular differentiation, and it is shown that this epigenetic inheritance is based on positive feedback within the sporulation phosphorelay.
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Controlling competence in Bacillus subtilis: shared use of regulators
TL;DR: The different regulation pathways which make up the gene regulation network that controls the development of competence are described, and their connections to other adaptive processes in B. subtilis are discussed.
Journal ArticleDOI
Localisation of DivIVA by targeting to negatively curved membranes
Rok Lenarcic,Sven Halbedel,Loek Visser,Michael W. Shaw,Ling Juan Wu,Jeff Errington,Davide Marenduzzo,Leendert W. Hamoen +7 more
TL;DR: It is shown that DivIVA binds to liposomes, and that the N terminus harbours the membrane targeting sequence, which may explain whyDivIVA localises at cell division sites and cell poles.
Journal ArticleDOI
Daptomycin inhibits cell envelope synthesis by interfering with fluid membrane microdomains
Anna Müller,Michaela Wenzel,Henrik Strahl,Fabian Grein,Terrens N. V. Saaki,Bastian Kohl,Tjalling Siersma,Julia E. Bandow,Hans-Georg Sahl,Tanja Schneider,Leendert W. Hamoen +10 more
TL;DR: It is reported that daptomycin perturbs fluid microdomains in bacterial cell membranes, thereby interfering with membrane-bound cell wall and lipid synthesis processes, and adding a different perspective as to how membrane-active antibiotics can kill bacteria.