M
Michaela Wenzel
Researcher at University of Amsterdam
Publications - 40
Citations - 1873
Michaela Wenzel is an academic researcher from University of Amsterdam. The author has contributed to research in topics: Membrane & Membrane fluidity. The author has an hindex of 20, co-authored 35 publications receiving 1386 citations. Previous affiliations of Michaela Wenzel include VU University Medical Center & Chalmers University of Technology.
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Journal ArticleDOI
Daptomycin inhibits cell envelope synthesis by interfering with fluid membrane microdomains
Anna Müller,Michaela Wenzel,Henrik Strahl,Fabian Grein,Terrens N. V. Saaki,Bastian Kohl,Tjalling Siersma,Julia E. Bandow,Hans-Georg Sahl,Tanja Schneider,Leendert W. Hamoen +10 more
TL;DR: It is reported that daptomycin perturbs fluid microdomains in bacterial cell membranes, thereby interfering with membrane-bound cell wall and lipid synthesis processes, and adding a different perspective as to how membrane-active antibiotics can kill bacteria.
Journal ArticleDOI
Small cationic antimicrobial peptides delocalize peripheral membrane proteins
Michaela Wenzel,Alina Iulia Chiriac,Andreas Otto,Dagmar Zweytick,Caroline May,Catherine Schumacher,Ronald Gust,H. Bauke Albada,Maya Penkova,Ute Krämer,Ralf Erdmann,Nils Metzler-Nolte,Suzana K. Straus,Erhard Bremer,Dörte Becher,Heike Brötz-Oesterhelt,Hans-Georg Sahl,Julia E. Bandow +17 more
TL;DR: It is shown that peptide integration into the membrane causes delocalization of essential peripheral membrane proteins essential for respiration and cell-wall biosynthesis, limiting cellular energy and undermining cell- wall integrity.
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Analysis of the mechanism of action of potent antibacterial hetero-tri-organometallic compounds: a structurally new class of antibiotics.
Michaela Wenzel,Malay Patra,Christoph Helmut Rudi Senges,Ingo Ott,Jennifer Janina Stepanek,António Costa Pinto,Pascal Prochnow,Cuong Vuong,Sina Langklotz,Nils Metzler-Nolte,Julia E. Bandow +10 more
TL;DR: The organometallics described here target the cytoplasmic membrane, a clinically proven antibacterial target structure, feature a bactericidal but non-bacteriolytic mode of action and limited cytotoxicity within the limits of solubility.
Journal ArticleDOI
Multitarget Approaches against Multiresistant Superbugs
Declan A. Gray,Michaela Wenzel +1 more
TL;DR: An overview of antibacterial multitarget approaches and the mechanisms behind them is provided, which show some mechanisms of action presuppose multiple targets or at least multiple effects and are therefore particularly promising.
Journal ArticleDOI
Synthesis and Biological Evaluation of Ferrocene-Containing Bioorganometallics Inspired by the Antibiotic Platensimycin Lead Structure
Malay Patra,Gilles Gasser,Gilles Gasser,Michaela Wenzel,Klaus Merz,Julia E. Bandow,Nils Metzler-Nolte +6 more
TL;DR: The first ferrocene-containing bioorganometallic compounds based on the platensimycin lead structure were reported in this paper, namely 3-(4,4-diferrocenoylpentanamido)-2, 4-dihydroxybenzoic acid (2), 3-( 4, 4diferricoenoylbutanamidol)-2.4dihdioxioxioxylbutanamide (3), 3-{4]-acetylferrocenoylel butanamide (4)-but