Lei Chang

TL;DR: In this article , the authors examined the cellular responses to two chemicals, caffeine and coumarin, by generating and integrating multi-omic data from multi-dose and multi-time point transcriptomic, proteomic and phosphoproteomic experiments.

TL;DR: A higher resolution mass spectrometry (MS) interpretation engine might provide an opportunity to identify these buried MPs in complex samples by the combination with multi-tissue large-scale proteomics.

TL;DR: It is demonstrated that the previously developed tandem hybrid ubiquitin-binding domain (ThUBD) chemically labeled with a reporter group such as horseradish peroxidase (Thubi-HRP) could significantly improve the robustness and sensitivity of polyubiquitination signal detection.

TL;DR: Proteomics covering posttranslational modifications can be utilized to provide a more complete coverage of chemical-induced cellular alteration and supplement transcriptomics-based health safety decision making as the cost becomes more affordable.

TL;DR: Zhang et al. as mentioned in this paper used an in-house developed acetylated LysargiNase to identify peptides other than tryptic peptides, which can identify additional novel peptides for N-terminal correction and ORF identification.