Y
Yuan Gao
Researcher at Protein Sciences
Publications - 33
Citations - 1504
Yuan Gao is an academic researcher from Protein Sciences. The author has contributed to research in topics: Ubiquitin & Ubiquitin ligase. The author has an hindex of 16, co-authored 28 publications receiving 1199 citations. Previous affiliations of Yuan Gao include University of Texas at Austin & University of Texas MD Anderson Cancer Center.
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Journal ArticleDOI
The Skp2-SCF E3 ligase regulates akt ubiquitination, glycolysis, herceptin sensitivity, and tumorigenesis
Chia Hsin Chan,Chien Feng Li,Chien Feng Li,Wei Lei Yang,Wei Lei Yang,Yuan Gao,Yuan Gao,Szu Wei Lee,Szu Wei Lee,Zizhen Feng,Hsuan-Ying Huang,Kelvin K C Tsai,Leo G. Flores,Yiping Shao,John D. Hazle,Dihua Yu,Dihua Yu,Wenyi Wei,Dos D. Sarbassov,Dos D. Sarbassov,Mien Chie Hung,Mien Chie Hung,Mien Chie Hung,Keiichi I. Nakayama,Hui Kuan Lin,Hui Kuan Lin +25 more
TL;DR: It is suggested that distinct E3 ligases are utilized by diverse growth factors for Akt activation and that targeting glycolysis sensitizes Her2-positive tumors to Herceptin treatment.
Journal ArticleDOI
Pharmacological Inactivation of Skp2 SCF Ubiquitin Ligase Restricts Cancer Stem Cell Traits and Cancer Progression
Chia Hsin Chan,John Morrow,John Morrow,Chien Feng Li,Yuan Gao,Yuan Gao,Guoxiang Jin,Asad Moten,Asad Moten,Loren J. Stagg,John E. Ladbury,Zhen Cai,Dazhi Xu,Christopher J. Logothetis,Mien Chie Hung,Mien Chie Hung,Mien Chie Hung,Shuxing Zhang,Shuxing Zhang,Hui Kuan Lin,Hui Kuan Lin +20 more
TL;DR: Pharmacological evidence that Skp2 is a promising target for restricting cancer stem cell and cancer progression is provided using high-throughput in silico screening of large and diverse chemical libraries.
Journal ArticleDOI
Skp2 E3 Ligase Integrates ATM Activation and Homologous Recombination Repair by Ubiquitinating NBS1
Juan Wu,Xian Zhang,Xian Zhang,Ling Zhang,Ling Zhang,Ching Yuan Wu,Ching Yuan Wu,Abdol Hossein Rezaeian,Chia Hsin Chan,Ju Mei Li,Jing Wang,Yuan Gao,Yuan Gao,Fei Han,Fei Han,Yun Seong Jeong,Yun Seong Jeong,Xiandao Yuan,Kum Kum Khanna,Jianping Jin,Jianping Jin,Yi Xin Zeng,Hui Kuan Lin,Hui Kuan Lin +23 more
TL;DR: It is shown that Skp2 E3 ligase is a key component for the MRN complex-mediated ATM activation in response to DSBs, andSkp2-mediatetd NBS1 ubiquitination as a vital event for ATM activation for DNA damage is identified.
Journal ArticleDOI
SETDB1-mediated methylation of Akt promotes its K63-linked ubiquitination and activation leading to tumorigenesis.
Guihua Wang,Guihua Wang,Jie Long,Jie Long,Yuan Gao,Weina Zhang,Fei Han,Chuan Xu,Li Sun,Li Sun,Shun-Chin Yang,Jingqin Lan,Zhenlin Hou,Zhen Cai,Guoxiang Jin,Che-Chia Hsu,Yu Hui Wang,Junbo Hu,Tsai Yu Chen,Hong-yu Li,Min Gyu Lee,Hui Kuan Lin,Hui Kuan Lin,Hui Kuan Lin +23 more
TL;DR: It is shown that Akt methylation by SETDB1 is recognized by demethylase JMJD2A, which then recruits E3 ligases to induce K63-linked Akt ubiquitination, leading to Akt activation and tumorigenesis.
Journal ArticleDOI
K63-linked ubiquitination in kinase activation and cancer.
Guocan Wang,Yuan Gao,Yuan Gao,Liren Li,Guoxiang Jin,Guoxiang Jin,Zhen Cai,Zhen Cai,Jui-I Chao,Jui-I Chao,Hui Kuan Lin +10 more
TL;DR: The advancement in the understanding of the novel functions of ubiquitination in signal transduction pathways downstream of growth factor receptors may provide novel paradigms for the treatment of human cancers.